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Serving leading biopharmaceutical companies globally:

Daiichi Sankyo
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Generated: December 15, 2017

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Claims for Patent: 5,180,668

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Claims for Patent: 5,180,668

Title: Hirudin derivative
Abstract:A hirudin derivative which has the N-terminal amino acid sequence Leu-Thr-Tyr-Thr-Asp shows high biological activity. Moreover, this hirudin derivative can be obtained very efficiently by genetic engineering preparation in yeasts.
Inventor(s): Crause; Peter (Offenbach, DE), Habermann; Paul (Frankfurt am Main, DE), Tripier; Dominique (Eppstein/Taunus, DE)
Assignee: Hoechst Aktiengesellschaft (Frankfurt am Main, DE)
Application Number:07/295,422
Patent Claims: 1. A hirudin derivative with the amino acid sequence ##STR23##

2. DNA coding for the polypeptide having the amino acid sequence as claimed in claim 1.

3. Vectors containing a DNA sequence as claimed in claim 2.

4. A process for the preparation of a polypeptide as claimed in claim 1, which comprises expression of a DNA as claimed in claim 2 in a host cell.

5. The process as claimed in claim 4, wherein the host cell is a yeast cell.

6. A pharmaceutical containing a polypeptide as claimed in claim 1.
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Serving leading biopharmaceutical companies globally:

Daiichi Sankyo
Argus Health
Cantor Fitzgerald

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