Claims for Patent: 5,180,668
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Summary for Patent: 5,180,668
| Title: | Hirudin derivative |
| Abstract: | A hirudin derivative which has the N-terminal amino acid sequence Leu-Thr-Tyr-Thr-Asp shows high biological activity. Moreover, this hirudin derivative can be obtained very efficiently by genetic engineering preparation in yeasts. |
| Inventor(s): | Crause; Peter (Offenbach, DE), Habermann; Paul (Frankfurt am Main, DE), Tripier; Dominique (Eppstein/Taunus, DE) |
| Assignee: | Hoechst Aktiengesellschaft (Frankfurt am Main, DE) |
| Application Number: | 07/295,422 |
| Patent Claims: |
1. A hirudin derivative with the amino acid sequence ##STR23##
2. DNA coding for the polypeptide having the amino acid sequence as claimed in claim 1. 3. Vectors containing a DNA sequence as claimed in claim 2. 4. A process for the preparation of a polypeptide as claimed in claim 1, which comprises expression of a DNA as claimed in claim 2 in a host cell. 5. The process as claimed in claim 4, wherein the host cell is a yeast cell. 6. A pharmaceutical containing a polypeptide as claimed in claim 1. |
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ISSN: 2162-2639
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Friedman, Yali. "DrugPatentWatch" DrugPatentWatch, thinkBiotech, 2024, www.DrugPatentWatch.com.
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