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Serving leading biopharmaceutical companies globally:

Federal Trade Commission
Merck
Fish and Richardson
Healthtrust
US Army
Cantor Fitzgerald
Fuji
Deloitte
Mallinckrodt
AstraZeneca

Generated: February 23, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,658,021

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Summary for Patent: 4,658,021
Title: Methionyl human growth hormone
Abstract:Described are methods and means for the construction and microbial expression of quasi-synthetic genes arising from the combination of organic synthesis and enzymatic reverse transcription from messenger RNA sequences incomplete from the standpoint of the desired protein product. Preferred products of expression lack bio-inactivating leader sequences common in eukaryotic expression products but problematic with regard to microbial cleavage to yield bioactive material. Illustrative is a preferred embodiment in which a gene coding for human growth hormone (useful in, e.g., treatment of hypopituitary dwarfism) is constructed and expressed.
Inventor(s): Goeddel; David V. (Burlingame, CA), Heyneker; Herbert L. (Burlingame, CA)
Assignee: Genentech, Inc. (So. San Francisco, CA)
Application Number:06/654,340
Patent Claim Types:
see list of patent claims
Compound;

Drugs Protected by US Patent 4,658,021

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Serving hundreds of leading biopharmaceutical companies globally:

Medtronic
Moodys
Dow
Deloitte
AstraZeneca
US Army
Argus Health
Cerilliant
UBS

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