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Serving hundreds of leading biopharmaceutical companies globally:

US Army
Colorcon
UBS
Deloitte
McKesson
Argus Health
Farmers Insurance
Mallinckrodt
Merck

Generated: June 20, 2018

DrugPatentWatch Database Preview

Details for Patent: 4,658,021

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Summary for Patent: 4,658,021
Title: Methionyl human growth hormone
Abstract:Described are methods and means for the construction and microbial expression of quasi-synthetic genes arising from the combination of organic synthesis and enzymatic reverse transcription from messenger RNA sequences incomplete from the standpoint of the desired protein product. Preferred products of expression lack bio-inactivating leader sequences common in eukaryotic expression products but problematic with regard to microbial cleavage to yield bioactive material. Illustrative is a preferred embodiment in which a gene coding for human growth hormone (useful in, e.g., treatment of hypopituitary dwarfism) is constructed and expressed.
Inventor(s): Goeddel; David V. (Burlingame, CA), Heyneker; Herbert L. (Burlingame, CA)
Assignee: Genentech, Inc. (So. San Francisco, CA)
Application Number:06/654,340
Patent Claim Types:
see list of patent claims
Compound;

Drugs Protected by US Patent 4,658,021

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Family Members for US Patent 4,658,021

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina 244341 ➤ Try a Free Trial
Austria 112802 ➤ Try a Free Trial
Austria 232237 ➤ Try a Free Trial
Austria 82324 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Argus Health
Accenture
AstraZeneca
McKesson
Merck
McKinsey
Julphar
QuintilesIMS
Federal Trade Commission

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