Details for Patent: 12,685,727
Which drugs does patent 12,685,727 protect, and when does it expire?
Patent 12,685,727 protects ZORYVE and is included in one NDA.
This patent has forty-one patent family members in thirteen countries.
Summary for Patent: 12,685,727
| Title: | Method for reducing side effects from administration of phosphodiesterase-4 inhibitors |
| Abstract: | A method for altering the PK profile of a pharmaceutical formulation containing a PDE-4 inhibitor, such as roflumilast, to reduce the spike in Cmax. The spike in Cmax is reduced by topically administering the PDE-4 inhibitor in combination with one or more phosphate ester surfactants. Reducing the spike in Cmax will reduce gastrointestinal side effects and result in better patient compliance. |
| Inventor(s): | David W. Osborne |
| Assignee: | Arcutis Biotherapeutics Inc |
| Application Number: | US19/444,809 |
|
Patent Claim Types: see list of patent claims | Use; Composition; Formulation; |
Drugs Protected by US Patent 12,685,727
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Arcutis | ZORYVE | roflumilast | CREAM;TOPICAL | 215985-003 | Oct 4, 2025 | RX | Yes | Yes | 12,685,727 | ⤷ Start Trial | TOPICAL TREATMENT OF MILD TO MODERATE ATOPIC DERMATITIS IN PEDIATRIC PATIENTS 2 TO 5 YEARS OF AGE | ⤷ Start Trial | ||||
| >Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
International Family Members for US Patent 12,685,727
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
|---|---|---|---|---|---|
| Australia | 2018282098 | ⤷ Start Trial | |||
| Australia | 2021214399 | ⤷ Start Trial | |||
| Brazil | 112019025748 | ⤷ Start Trial | |||
| >Country | >Patent Number | >Estimated Expiration | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration |
