Last Updated: September 24, 2026

Details for Patent: 12,357,602

Name: Drug Patent Intelligence for US Patent 12357602
Creator: DrugPatentWatch
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Which drugs does patent 12,357,602 protect, and when does it expire?

Patent 12,357,602 protects TWYNEO and is included in one NDA.

This patent has ten patent family members in ten countries.

Summary for Patent: 12,357,602

Title:	Compositions comprising encapsulated tretinoin
Abstract:	The present application is directed to compositions comprising microcapsules comprising encapsulated tretinoin, wherein the microcapsule size is less than 50 μm; and to methods of use thereof.
Inventor(s):	Ofer Toledano, Karine Neimann, Maya Erlich, Dorit Marco
Assignee:	Mayne Pharma LLC
Application Number:	US16/033,260
Patent Claim Types: see list of patent claims	Use; Composition; Formulation; Dosage form;

Drugs Protected by US Patent 12,357,602

Glossary

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
Mayne Pharma	TWYNEO	benzoyl peroxide; tretinoin	CREAM;TOPICAL	214902-001	Jul 26, 2021		RX	Yes	Yes	⤷ Start Trial	⤷ Start Trial	Y			TOPICAL TREATMENT OF ACNE	⤷ Start Trial
>Applicant	>Tradename	>Generic Name	>Dosage	>NDA	>Approval Date	>TE	>Type	>RLD	>RS	>Patent No.	>Patent Expiration	>Product	>Substance	>Delist Req.	>Patented / Exclusive Use	>Submissiondate

International Family Members for US Patent 12,357,602

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Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Canada	3069359	⤷ Start Trial
China	110869013	⤷ Start Trial
European Patent Office	3651756	⤷ Start Trial
Spain	3040940	⤷ Start Trial
Croatia	P20251185	⤷ Start Trial
Hungary	E073201	⤷ Start Trial
Japan	2020527140	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration	>Supplementary Protection Certificate	>SPC Country	>SPC Expiration

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