Last Updated: November 8, 2026

Details for Patent: 12,053,546

Name: Drug Patent Intelligence for US Patent 12053546
Creator: DrugPatentWatch
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Which drugs does patent 12,053,546 protect, and when does it expire?

Patent 12,053,546 protects TWYNEO and is included in one NDA.

This patent has sixteen patent family members in eleven countries.

Summary for Patent: 12,053,546

Title:	Stabilized topical formulations containing core-shell microcapsules
Abstract:	The present disclosure relates to compositions for topical application, where the compositions comprise microcapsules having a core that comprises benzoyl peroxide and a shell that comprises an inorganic polymer, microcapsules having a core that comprises a retinoid and a shell that comprises an inorganic polymer, and a stabilizing agent. The composition can be in a variety of forms, such as emulsion and gel.
Inventor(s):	Ofer Toledano, Haim Bar-Simantov, Hanan Sertchook
Assignee:	Barclays Bank PLC , Medicis Pharmaceutical Corp , Mayne Pharma LLC
Application Number:	US13/537,646
Patent Claim Types: see list of patent claims	Use; Composition; Compound; Dosage form;

Drugs Protected by US Patent 12,053,546

Glossary

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
Mayne Pharma	TWYNEO	benzoyl peroxide; tretinoin	CREAM;TOPICAL	214902-001	Jul 26, 2021		RX	Yes	Yes	12,053,546	⤷ Start Trial	Y				⤷ Start Trial
>Applicant	>Tradename	>Generic Name	>Dosage	>NDA	>Approval Date	>TE	>Type	>RLD	>RS	>Patent No.	>Patent Expiration	>Product	>Substance	>Delist Req.	>Patented / Exclusive Use	>Submissiondate

International Family Members for US Patent 12,053,546

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Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Australia	2012277322	⤷ Start Trial
Brazil	112013031813	⤷ Start Trial
Canada	2834681	⤷ Start Trial
China	103732217	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration	>Supplementary Protection Certificate	>SPC Country	>SPC Expiration

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