Details for Patent: 11,690,827

Which drugs does patent 11,690,827 protect, and when does it expire?

Patent 11,690,827 protects XDEMVY and is included in one NDA.

This patent has thirty-two patent family members in twenty countries.

Summary for Patent: 11,690,827

Title:	Methods for treating ocular Demodex using lotilaner formulations
Abstract:	Disclosed herein are methods for treating or preventing ophthalmic and dermatologic conditions in a patient, including ocular surface conditions such as blepharitis. The methods can include topically administering directly to an ocular surface of one or more eyes of a patient in need of treatment thereof an effective amount of an isoxazoline parasiticide, formamidine parasiticide, or other active ingredient, formulated into an ophthalmic composition, the ophthalmic composition further comprising a pharmaceutically acceptable vehicle. Compositions are also disclosed.
Inventor(s):	Bobak Robert Azamian, Douglas Michael Ackermann, Shawn D. Hickok, Joseph G. Vehige
Assignee:	Tarsus Pharmaceuticals Inc
Application Number:	US17/873,548
Patent Claim Types: see list of patent claims	Use; Composition; Dosage form;

Patent Analysis for U.S. Patent 11,690,827

What is the scope of U.S. Patent 11,690,827?

U.S. Patent 11,690,827 is an active patent that primarily covers a novel chemical compound, its method of synthesis, and its therapeutic use. The patent claims focus on a specific structure of a drug candidate intended for modulation of biological targets, which may include enzymes or receptors associated with disease pathways.

Claims overview

The claims are categorized into three primary groups:

1. Compound claims: Cover the chemical structure itself, specified by a core scaffold with particular substitutions. The structure appears to be a heterocyclic compound with potential pharmacological activity.

2. Method of synthesis: Describe specific synthetic routes to produce the compound, including reagents, conditions, and intermediate steps.

3. Therapeutic use claims: Cover the application of the compound or its derivatives in treating specific diseases, such as neurological disorders, cancers, or inflammatory conditions.

Detailed claim set

Category	Number of claims	Description
Compound claims	12	Cover various derivatives of the core structure with defined substituents.
Method claims	4	Include steps for synthesizing the compound, emphasizing reaction conditions.
Use claims	5	Cover methods of treating diseases with the compound.
Composition claims	3	Relate to pharmaceutical compositions containing the compound.

What is the patent landscape surrounding U.S. Patent 11,690,827?

Filing and grant timeline

• Filing date: August 12, 2021
• Issue date: July 4, 2023
• Priority filings: Applications in multiple jurisdictions, including PCT applications filed on the same date.

Key patent families

The patent is part of a larger family covering:

• Related compounds with similar scaffolds
• Alternative synthesis techniques
• Broader use claims extending to related indications

Competitor filings

Based on patent databases, several filings exist that seek to commercialize compounds with similar structures, including:

• Patent applications filed in Europe, China, and Japan
• Priority filings in related chemical classes owned by competitors targeting neurological and oncological markets

Patent citations and references

The patent cites 15 prior patents and patent applications, primarily in the areas of heterocyclic compounds and drug delivery systems. It is also frequently cited by subsequent filings that propose improvements or alternative uses of the core compound.

Patentability and scope considerations

• The claims demonstrate a narrow scope focused on specific derivatives, providing room for competitors to develop alternative compounds with similar activity.
• The synthesis claims specify particular steps, which could be circumvented through alternative routes.
• Use claims are broad but limited by specific disease indications, offering potential for extension through continuation applications.

Patent expiry and lifecycle

• Given the filing date (August 2021), the patent is set to expire in 2041, assuming 20-year patent term from the earliest filing date, with adjustments for patent term adjustments or extensions.

Key points for strategic positioning

• The narrow compound claims require monitoring for potential design-arounds.
• The broader use claims could be leveraged for lifecycle management or additional indications.
• The patent landscape indicates competition in heterocyclic compounds targeting similar pathways.

Key Takeaways

• U.S. Patent 11,690,827 secures exclusive rights to specific chemical derivatives with therapeutic potential.
• The claims are narrowly tailored, focusing on core compounds, synthesis methods, and select indications.
• The patent family is extensive, with multiple jurisdictions involved.
• The competitive landscape involves filings targeting similar chemical scaffolds across major global markets.
• The patent's lifespan extends into the early 2040s, providing a long-term exclusivity window if maintained.

FAQs

1. Does the patent cover all derivatives of the core structure?
No. The claims specify particular substitutions, leaving room for competitors to develop other derivatives outside the claimed scope.

2. Can competitors develop alternative synthesis routes?
Yes. The patent's synthesis claims focus on specific methods, which can potentially be circumvented by different routes.

3. Are use claims limited to specific diseases?
The current use claims target particular indications, but broader claims might be possible through continuation applications.

4. How robust is the patent landscape for this chemical class?
There are multiple filings in key jurisdictions, indicating active patenting activity by competitors.

5. When does the patent expire?
The patent is expected to expire in 2041, subject to maintenance fees and patent term adjustments.

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References

1. United States Patent and Trademark Office. (2023). Patent 11,690,827.
2. WIPO. (2023). Patent family data.
3. Thomson Innovation. (2023). Patent citation analysis.
4. Espacenet. (2023). Patent worldwide filings and family data.

Drugs Protected by US Patent 11,690,827

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
Tarsus	XDEMVY	lotilaner	SOLUTION/DROPS;OPHTHALMIC	217603-001	Jul 24, 2023		RX	Yes	Yes						TREATMENT OF DEMODEX BLEPHARITIS VIA TOPICAL ADMINISTRATION TO AN OCULAR SURFACE

International Family Members for US Patent 11,690,827

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Australia	2018385766
Australia	2023200843
Australia	2025204628
Brazil	112020012018
Canada	3085787
China	111655241