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Last Updated: February 8, 2025

Details for Patent: 10,906,903


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Summary for Patent: 10,906,903
Title:Synthetic methods for preparation of (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyr- ido[2,1,-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate)
Abstract: Provided herein are processes for the preparation of (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyr- ido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), or a solvate, hydrate, or polymorph thereof.
Inventor(s): McGee; Kevin (San Diego, CA), Li; Bin-Feng (Suzhou Industrial Park, CN), Branum; Shawn (San Diego, CA)
Assignee: Neurocrine Biosciences, Inc. (San Diego, CA)
Application Number:16/929,714
Patent Claim Types:
see list of patent claims
Composition; Compound;
Patent landscape, scope, and claims:

Analyzing the Scope and Claims of United States Patent 10,906,903

Introduction

When analyzing a patent, particularly one like U.S. Patent 10,906,903, it is crucial to understand the scope of the patent, its claims, and how it fits into the broader patent landscape. This analysis is essential for determining the patent's validity, potential infringement, and strategic value.

Understanding the Patent

Patent Overview

U.S. Patent 10,906,903 is part of a series of patents held by Neurocrine Biosciences, Inc., and is involved in several patent infringement cases, as seen in recent litigation documents[2][5].

Technology and Field

The patent pertains to pharmaceuticals, specifically relating to valbenazine tosylate, a drug used for treating certain neurological conditions. Understanding the specific technology and field is vital for assessing the patent's relevance and impact.

Scope of the Patent

Claims Analysis

The claims of a patent are its most critical components, as they define the scope of protection. For U.S. Patent 10,906,903, the claims would typically include:

  • Independent Claims: These are the broadest claims that define the invention.
  • Dependent Claims: These claims are narrower and depend on the independent claims, often adding specific details or limitations.

To analyze these claims, one would use tools like Claim Coverage Matrices and Claim Charts, which help in categorizing and visualizing the claims and their scope concepts. This process ensures that all aspects of the patent are understood and that any gaps or opportunities in the patent coverage are identified[3].

Scope Concepts

Scope concepts are overarching themes that link claims on similar patents. Analyzing these concepts helps in filtering, searching, and accurately analyzing large numbers of patent claims. This method is particularly useful for determining whether a particular scope concept is applicable to a target product or method[3].

Patent Landscape

Global Context

To fully understand the patent landscape, it is essential to look beyond the U.S. and examine international patent databases. Tools like the Global Dossier and the Common Citation Document (CCD) provide access to file histories and citation data from participating IP offices, helping to identify related applications and prior art globally[1].

Competitor Patents

Analyzing competitor patents in the same field can reveal potential overlaps or gaps in coverage. This involves searching databases such as those provided by the European Patent Office (EPO), Japan Patent Office (JPO), and the World Intellectual Property Organization (WIPO)[1].

Litigation and Infringement

Recent Litigation

U.S. Patent 10,906,903 has been involved in several patent infringement cases, notably against companies like Crystal Pharmaceutical and Sandoz Inc. These cases highlight the importance of the patent in protecting Neurocrine Biosciences' intellectual property. The litigation documents provide insights into how the patent claims are being enforced and challenged[2][5].

ANDA Filings

The patent is also relevant in the context of Abbreviated New Drug Applications (ANDAs) filed by generic drug manufacturers. These filings often trigger patent infringement lawsuits, as seen in the cases involving Neurocrine Biosciences, where the company alleges that the generic products infringe on their patents[2][5].

Strategic Value

Claim Coverage and Gaps

Using tools like ClaimScape® software, companies can generate interactive claim charts to review patent coverage. This helps in identifying gaps in current coverage and highlighting future design opportunities. The strategic value of the patent can be assessed by categorizing the scope concepts into high, medium, or low value, indicating their current and potential future importance[3].

Future Development

The patent's scope and claims can also guide future research and development. By identifying areas where claim coverage is lacking, companies can focus their development efforts to strengthen their intellectual property portfolio.

Key Takeaways

  • Claims Analysis: Understanding the independent and dependent claims is crucial for defining the scope of protection.
  • Scope Concepts: Analyzing overarching scope concepts helps in visualizing and managing large numbers of patent claims.
  • Global Context: Examining international patent databases is essential for a comprehensive understanding of the patent landscape.
  • Litigation: Recent litigation cases provide valuable insights into the enforcement and challenges of the patent claims.
  • Strategic Value: Identifying gaps and opportunities in claim coverage is vital for strategic decision-making and future development.

FAQs

  1. What is the significance of U.S. Patent 10,906,903 in the pharmaceutical industry?

    • U.S. Patent 10,906,903 is significant as it protects Neurocrine Biosciences' intellectual property related to valbenazine tosylate, a drug used for treating neurological conditions.
  2. How can Claim Coverage Matrices help in analyzing patent claims?

    • Claim Coverage Matrices help in categorizing and visualizing the claims and their scope concepts, making it easier to identify gaps or opportunities in patent coverage.
  3. What is the role of the Global Dossier in patent searching?

    • The Global Dossier provides access to file histories and citation data from participating IP offices, helping users to see the patent family for a specific application and related applications filed at other offices.
  4. Why is it important to analyze competitor patents in the same field?

    • Analyzing competitor patents helps in identifying potential overlaps or gaps in coverage, which is crucial for maintaining a strong intellectual property position.
  5. How do ANDA filings relate to patent infringement cases?

    • ANDA filings by generic drug manufacturers can trigger patent infringement lawsuits if the generic products are alleged to infringe on existing patents, as seen in the cases involving Neurocrine Biosciences.

Sources

  1. USPTO - Search for patents[1]
  2. IN THE UNITED STATES DISTRICT COURT FOR THE DISTRICT OF DELAWARE - Neurocrine Biosciences, Inc. v. Crystal Pharmaceutical (Suzhou) Co., Ltd. et al.[2]
  3. Patent Analytics | Intellectual Property Law[3]
  4. Guidelines for Assessing Enablement in Utility Applications and ...[4]
  5. IN THE UNITED STATES DISTRICT COURT FOR THE DISTRICT OF DELAWARE - Neurocrine Biosciences, Inc. v. Sandoz Inc., Sandoz AG and Sandoz International GmbH[5]

More… ↓

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Drugs Protected by US Patent 10,906,903

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Neurocrine INGREZZA valbenazine tosylate CAPSULE;ORAL 209241-001 Apr 11, 2017 AB RX Yes No 10,906,903 ⤷  Try for Free Y Y ⤷  Try for Free
Neurocrine INGREZZA valbenazine tosylate CAPSULE;ORAL 209241-003 Apr 23, 2021 AB RX Yes No 10,906,903 ⤷  Try for Free Y Y ⤷  Try for Free
Neurocrine INGREZZA valbenazine tosylate CAPSULE;ORAL 209241-002 Oct 4, 2017 AB RX Yes Yes 10,906,903 ⤷  Try for Free Y Y ⤷  Try for Free
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

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