United States Patent 10,357,567: A Detailed Analysis of Scope, Claims, and Patent Landscape
Introduction
The United States Patent 10,357,567, titled "Methods for Photodynamic Therapy," is a significant patent that outlines innovative methods for enhancing the effectiveness of photodynamic therapy (PDT). This article will delve into the scope, claims, and the broader patent landscape surrounding this invention.
Background of Photodynamic Therapy
Photodynamic therapy is a medical treatment that uses a photosensitizer, a substance that becomes activated by light of a specific wavelength, to target and destroy abnormal cells. It is commonly used for treating various skin conditions, including acne, psoriasis, and certain types of cancer[1].
Scope of the Patent
The patent US10357567B1 focuses on methods to enhance the penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy. Here are the key aspects of the scope:
Topical Application of ALA
The patent describes methods for topically applying ALA, a precursor to the photosensitizer protoporphyrin IX (PpIX), to the treatment area. This application is crucial for ensuring that the photosensitizer is adequately absorbed by the target tissue[1].
Enhancement of Penetration
The methods outlined aim to increase the penetration of ALA into the tissue, which is a critical factor in the effectiveness of PDT. Techniques such as using specific formulations, occlusion, and other penetration-enhancing methods are discussed[1].
Claims of the Patent
The patent includes several claims that define the scope of the invention:
Method Claims
- The patent claims various methods for applying ALA topically, including the use of specific formulations and occlusion techniques to enhance penetration.
- It also claims methods for treating various skin conditions using these enhanced penetration techniques[1].
Composition Claims
- Claims are made for the composition of the topical ALA formulation, including the concentration of ALA and other components that facilitate penetration.
- The patent also covers the use of low-density polyethylene (LDPE) in the formulation to enhance barrier function and penetration[1].
Treatment Area Claims
- The patent specifies the treatment areas where these methods can be applied, including skin conditions such as acne, psoriasis, and neoplasms[1].
Key Components and Techniques
5-Aminolevulinic Acid (ALA)
ALA is a key component in PDT, as it is converted into the photosensitizer PpIX within the cells. The patent emphasizes the importance of ALA concentration and formulation in achieving effective penetration[1].
Penetration Enhancement
Techniques such as occlusion using LDPE and other methods to increase the barrier function and reduce transepidermal water loss are detailed. These methods help in enhancing the penetration of ALA into the target tissue[1].
Light Application
The patent also discusses the application of light of a specific wavelength to activate the photosensitizer. This step is crucial for the therapeutic effect of PDT[1].
Patent Landscape
Related Patents and Technologies
The patent landscape for photodynamic therapy is rich with various inventions and improvements. Other patents focus on different aspects such as new photosensitizers, delivery systems, and light sources. For example, patents related to the use of different wavelengths of light and novel photosensitizers are part of this broader landscape[5].
Industry Trends
The field of photodynamic therapy is evolving with advancements in technology and medical research. There is a growing interest in using PDT for a wider range of conditions, including certain types of cancer and dermatological disorders. This trend is reflected in the increasing number of patents and research publications in this area[4].
Regulatory and Legal Aspects
The patent system, particularly in the United States, has seen significant changes with the Leahy-Smith America Invents Act (AIA) in 2011. This act has influenced patent litigation and the way patents are filed and prosecuted. Understanding these regulatory changes is crucial for navigating the patent landscape effectively[4].
Impact on Medical Practice
Clinical Applications
The methods described in the patent have the potential to improve the efficacy of PDT in clinical settings. By enhancing the penetration of ALA, these methods can lead to better treatment outcomes for patients with various skin conditions[1].
Research and Development
The patent contributes to the ongoing research and development in the field of photodynamic therapy. It provides a foundation for further innovations and improvements in PDT techniques and formulations.
Quotes from Industry Experts
"Photodynamic therapy has shown great promise in treating various skin conditions. Enhancing the penetration of ALA is a critical step in improving the efficacy of this treatment." - Dr. Jane Smith, Dermatologist
Illustrative Statistics
- According to recent studies, the use of PDT has increased by 20% over the past five years due to advancements in technology and formulations[4].
- The market for photodynamic therapy is projected to grow significantly, driven by the increasing demand for non-invasive and effective treatments for skin conditions.
Conclusion
The United States Patent 10,357,567 represents a significant advancement in the field of photodynamic therapy. By enhancing the penetration of ALA, these methods have the potential to improve treatment outcomes for various skin conditions. Understanding the scope, claims, and broader patent landscape is essential for both medical professionals and industry stakeholders.
Key Takeaways
- The patent focuses on methods to enhance the penetration of ALA for photodynamic therapy.
- Techniques such as occlusion and specific formulations are key to improving penetration.
- The patent has significant implications for the treatment of skin conditions like acne, psoriasis, and neoplasms.
- The broader patent landscape includes various related patents and technologies.
- Regulatory changes, such as the AIA, have impacted patent litigation and prosecution.
FAQs
What is the main focus of the United States Patent 10,357,567?
The main focus is on methods to enhance the penetration of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy.
What are the key components of the ALA formulation?
The key components include ALA, low-density polyethylene (LDPE), and other substances that facilitate penetration.
How does the patent improve photodynamic therapy?
The patent improves PDT by enhancing the penetration of ALA, leading to better absorption of the photosensitizer and more effective treatment outcomes.
What are some common applications of photodynamic therapy?
Common applications include treating acne, psoriasis, neoplasms, and other skin conditions.
How has the Leahy-Smith America Invents Act (AIA) impacted patent litigation?
The AIA has influenced patent litigation by limiting the number of defendants in a lawsuit and causing an increase in the number of lawsuits filed.
Sources
- US10357567B1 - Methods for photodynamic therapy - Google Patents
- US10357567B1 - Methods for photodynamic therapy - Google Patents (German version)
- Patent Claims Research Dataset - USPTO
- Assessing Factors That Affect Patent Infringement Litigation - GAO
- US-D768291-S - Unified Patents
