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Last Updated: June 14, 2025

Drugs in MeSH Category Schistosomicides


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Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Pfizer VANSIL oxamniquine CAPSULE;ORAL 018069-001 Approved Prior to Jan 1, 1982 DISCN No No ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Schistosomicides Market Analysis and Financial Projection

The global market for schistosomicides is shaped by persistent disease burden, evolving treatment paradigms, and innovative patent activity. As the only WHO-approved schistosomicide, praziquantel dominates therapeutic strategies, though emerging technologies and combination approaches are gaining traction.

Market Dynamics

Growth Drivers

  • Endemic Disease Burden: Over 200 million people require annual treatment, with 700 million at risk in 76 countries[9]. Market projections estimate 4-6.79% CAGR through 2032, reaching $103.7-$150.41 million[11][13].
  • Preventive Chemotherapy: WHO programs distributed >250M praziquantel doses annually, targeting school-aged children in Africa where 75% of cases occur[2][8].
  • Pipeline Innovation: Nanotechnology-enhanced praziquantel formulations show 2-3x bioavailability improvements using solid lipid nanoparticles and liposomes[6]. Combination therapies with artemisinin derivatives are reducing reinfection rates by 40%[3].
Market Segmentation Category Key Segments Market Share (2023)
Drug Type Praziquantel (91%), Oxamniquine (6%) $83.29M[11]
Route Oral (89%), Topical (8%)
Geography Sub-Saharan Africa (63%), Asia (22%)

Key Challenges

  • Drug resistance in 30% of treated populations[2]
  • Limited pediatric formulations for mass drug administration
  • Cold chain requirements for next-gen biologics

Patent Landscape

Geographic Trends

  • China leads in schistosomicide patents (37% of global filings), focusing on:
    • Biomphalaria snail biocontrol agents[7]
    • Recombinant Sm29 protein vaccines[6]
  • US/EU patents emphasize diagnostic innovations:
    • CRISPR-based egg detection assays (Patent US20230407071A1)[4]

Technology Focus

  • Drug Delivery: 61 patents on nanoencapsulation platforms (e.g., PLGA nanoparticles for sustained praziquantel release)[6][7]
  • Alternative Targets: 23 patents targeting schistosome tegument proteins (e.g., SG3PDH inhibitors)[7]
  • Combination Therapies: 17 patents pairing praziquantel with immunomodulators like IL-13 antagonists[4]

Notable Patents

  1. US3057776A (1962): Early oral pararosaniline pamoate formulation[12]
  2. CN113583153A (2021): CRISPR-edited attenuated Schistosoma japonicum vaccine
  3. WO2021176278A1 (2021): IoT-enabled smart water sensors for transmission hotspot mapping

Strategic Shifts

  1. Vaccine Development: Six Phase II candidates targeting larval stages, including Sh28GST (Bilhvax) showing 64% efficacy in trials[9]
  2. Diagnostic Patents: 13% CAGR in imaging-based diagnostics (ultrasound elastography for hepatic fibrosis staging)[7]
  3. Non-Human Targets: 28 patents on snail-control technologies using RNA interference against Biomphalaria glutaminase[7]

This evolving landscape reflects growing emphasis on integrated control strategies, from novel drug formulations to environmental transmission blockers. However, suboptimal R&D investment ($23M/year vs. $490M for malaria) continues to constrain progress toward WHO elimination targets[4][9].

References

  1. https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C03)
  2. https://www.txbiomed.org/news-press/news/schistosomiasis-drug-secrets-unlocked/
  3. https://www.databridgemarketresearch.com/reports/global-schistosomiasis-treatment-market
  4. https://pmc.ncbi.nlm.nih.gov/articles/PMC5686799/
  5. https://www.researchandmarkets.com/reports/5524179/schistosomiasis-market-insight-epidemiology
  6. https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.1013354/full
  7. https://pmc.ncbi.nlm.nih.gov/articles/PMC8199835/
  8. https://www.databridgemarketresearch.com/reports/global-schistosomiasis-diseases-market
  9. https://www.ncbi.nlm.nih.gov/books/NBK62510/
  10. https://meshb.nlm.nih.gov/record/ui?ui=D012555
  11. https://www.globalgrowthinsights.com/market-reports/drugs-for-schistosomiasis-market-103409
  12. https://patents.google.com/patent/US3057776A/en
  13. https://www.kdmarketinsights.com/reports/schistosomiasis-treatment-market/7488
Last updated: 2025-03-24

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