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Last Updated: June 13, 2025

Drugs in MeSH Category Oxidants


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Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Aclaris ESKATA hydrogen peroxide SOLUTION;TOPICAL 209305-001 Dec 14, 2017 DISCN Yes No 9,980,983 ⤷  Try for Free ⤷  Try for Free
Aclaris ESKATA hydrogen peroxide SOLUTION;TOPICAL 209305-001 Dec 14, 2017 DISCN Yes No 9,675,639 ⤷  Try for Free Y ⤷  Try for Free
Aclaris ESKATA hydrogen peroxide SOLUTION;TOPICAL 209305-001 Dec 14, 2017 DISCN Yes No 10,493,103 ⤷  Try for Free Y ⤷  Try for Free
Aclaris ESKATA hydrogen peroxide SOLUTION;TOPICAL 209305-001 Dec 14, 2017 DISCN Yes No 10,729,720 ⤷  Try for Free Y ⤷  Try for Free
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Oxidants Market Analysis and Financial Projection

The global market for antioxidant-related drugs and products is experiencing robust growth, driven by health trends and industrial applications. Valued at $4.09 billion in 2024, the market is projected to expand at a 6.80% CAGR, reaching $7.90 billion by 2034[1][6]. Concurrently, the patent landscape reflects intense innovation and strategic competition, particularly as high-value drugs face patent cliffs and new formulations emerge.


Market Dynamics

Growth Drivers

  • Health and Wellness Trends: Rising demand for dietary supplements, functional foods, and cosmetics fuels market expansion, with natural antioxidants (e.g., green tea, curcumin) displacing synthetic options due to the clean-label movement[1][9].
  • Extended Shelf-Life Needs: Antioxidants are critical in food preservation, reducing waste and enabling longer-lasting products[1][6].
  • Industrial Applications: Beyond pharmaceuticals, antioxidants are essential in plastics, rubber, and fuel additives, driven by Asia Pacific’s automotive and construction sectors[6][9].

Regional Insights

  • North America: Holds a 38% market share (2023), with the U.S. market projected to grow at 6.87% CAGR (2024–2034)[1].
  • Asia Pacific: Dominates with 43.8% market share (2024), driven by population growth and industrial demand[6].
  • Europe: Benefits from a strong cosmetics sector and automotive industry growth[6].

Key Challenges

  • Regulatory Scrutiny: Stringent safety standards for synthetic antioxidants push R&D toward natural alternatives[9].
  • Cost Pressures: Patent expirations (e.g., Ozempic in 2026[13]) accelerate generic competition, lowering prices but reducing innovator revenues[5][12].

Patent Landscape

Strategic Patenting Trends

  • Evergreening and Extensions: Companies modify formulations or dosages to extend exclusivity. For example, crystalline forms of drugs can secure new patents[4][8].
  • Combination Therapies: Patents covering drug mixtures (e.g., antivirals with antioxidants) create barriers to generic entry[4][14].

Emerging Innovations

  • Natural Antioxidants: Over 300 patents focus on phytochemicals like curcumin and vitamin C for periodontal disease and cancer[14].
  • Nrf2 Pathway Targets: Over 500 patents (2017–2020) explore Keap1/Nrf2 modulators for autoimmune and neurodegenerative diseases[10].

Notable Expirations and Impacts

Drug Company Expiration Impact
Stelara Johnson & Johnson 2025 Biosimilars to cut costs for Crohn’s treatment[2].
Ozempic Novo Nordisk 2026 15+ Chinese generics set to enter, reshaping pricing[13].
Tecfidera Biogen 2025 Generic competition to lower MS treatment costs[2].

Future Outlook

  • Technology Integration: AI and blockchain are streamlining patent searches and litigation, enhancing IP management[5].
  • Equity vs. Innovation: Balancing affordable access with R&D incentives remains critical, particularly in developing regions[5][12].

“The entry of cost-effective generics post-patent cliffs will reshape healthcare affordability, but innovators must prioritize novel formulations to retain market share.” [5][12]

This dynamic interplay between market growth and patent strategies underscores the antioxidants sector’s role in both public health and industrial innovation.

References

  1. https://www.precedenceresearch.com/antioxidants-market
  2. https://biopharmaapac.com/analysis/60/5727/25-high-value-drugs-losing-patent-protection-in-2025-what-it-means-for-healthcare.html
  3. https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D27)
  4. https://ipaccessmeds.southcentre.int/wp-content/uploads/2019/07/ICTSD-WHO-WorkingPaper.pdf
  5. https://www.pharmafocuseurope.com/articles/drug-patents-shape-pharma-competition
  6. https://www.fortunebusinessinsights.com/industry-reports/food-antioxidants-market-100789
  7. https://www.msif.org/wp-content/uploads/2022/03/DMTs-patent-overview-March-22.pdf
  8. https://www.treatmentactiongroup.org/wp-content/uploads/2021/11/hcv_tb_longacting_patent_trends.pdf
  9. https://www.transparencymarketresearch.com/antioxidants-market.html
  10. https://pmc.ncbi.nlm.nih.gov/articles/PMC7697445/
  11. https://pmc.ncbi.nlm.nih.gov/articles/PMC8431097/
  12. https://pmc.ncbi.nlm.nih.gov/articles/PMC3291824/
  13. https://journals.library.columbia.edu/index.php/stlr/blog/view/653
  14. https://pmc.ncbi.nlm.nih.gov/articles/PMC11117607/
  15. https://www.scielo.br/j/bjps/a/7xhpYMPhcnv79pqHbF5CBSr/
  16. https://pmc.ncbi.nlm.nih.gov/articles/PMC11274006/
Last updated: 2025-03-24

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