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Last Updated: June 16, 2025

Drugs in MeSH Category Incretins


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Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Invagen Pharms LINAGLIPTIN linagliptin TABLET;ORAL 208423-001 Sep 3, 2024 AB RX No No ⤷  Try for Free ⤷  Try for Free ⤷  Try for Free
Boehringer Ingelheim TRADJENTA linagliptin TABLET;ORAL 201280-001 May 2, 2011 AB RX Yes Yes ⤷  Try for Free ⤷  Try for Free Y ⤷  Try for Free
Merck Sharp Dohme JANUVIA sitagliptin phosphate TABLET;ORAL 021995-003 Oct 16, 2006 RX Yes Yes ⤷  Try for Free ⤷  Try for Free Y ⤷  Try for Free
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Incretins Market Analysis and Financial Projection

The incretin-based drug market is experiencing robust growth driven by rising diabetes prevalence and therapeutic advancements, while the patent landscape reveals extensive strategies to prolong market exclusivity through device patents and regulatory protections.

Market Dynamics

Growth Drivers
The global incretin-based drugs market, valued at $34.4 billion in 2022, is projected to reach $73.9 billion by 2032 at a 7.9% CAGR[5]. Key factors include:

  • Rising type 2 diabetes prevalence, affecting 90-95% of the 38 million U.S. diabetes patients[5][7].
  • Superior efficacy of GLP-1 receptor agonists, which held 74% market share in 2022 due to enhanced glucose control and weight loss benefits[4][5].
  • Recent approvals for formulations like Novo Nordisk’s oral semaglutide (Rybelsus) across multiple regions[5].

Regional Insights

  • North America dominates (45%+ share) due to advanced healthcare infrastructure and high diabetes awareness[8][14].
  • Asia-Pacific is the fastest-growing region (10.69% CAGR) with expanding access to generics and government healthcare initiatives[14][8].
  • Europe maintains steady growth through innovations like tirzepatide, which showed cardiovascular benefits in trials[6][13].

Patent Landscape

Key Strategies
Pharmaceutical companies employ multi-layered IP protection:

  • Device-centric patents: 54% of GLP-1 agonist patents target delivery mechanisms (e.g., injector pens) rather than active ingredients[10][13].
  • Patent clustering: Products average 19.5 patents, with Novo Nordisk’s semaglutide protected by formulation patents until 2031 and device patents extending exclusivity[6][13].
  • Regulatory exclusivities: Combined with patents, these provide ≥18 years of market protection post-approval[10][13].

Notable Developments

  • Incretin conjugates: Patents like US10232020B2 cover insulin-incretin hybrids to enhance therapeutic effects[2].
  • Multi-receptor agonists: WO2019125929A1 protects analogs targeting GIP, GLP-1, and glucagon receptors for improved efficacy[9][12].

Competitive Challenges

  • Generic barriers: Complex drug-device combinations and dense patent thickets have prevented generic entry for all GLP-1 agonists[13][10].
  • Cost pressures: Branded drugs face pricing scrutiny in Europe and emerging markets, though U.S. sales remain strong due to limited alternatives[8][14].

The interplay of demographic trends and IP strategies ensures sustained market growth, while regulatory reforms may be needed to balance innovation with accessibility[13][10].

References

  1. https://www.globenewswire.com/news-release/2024/02/20/2831955/0/en/Global-Incretin-Based-Drugs-Market-Report-2023-2029-with-Analysis-of-Leading-Market-Players-like-Eli-Lilly-and-Co-Boehringer-Ingelheim-Novo-Nordisk-and-AstraZeneca-Among-Others.html
  2. https://patents.google.com/patent/US10232020B2/en
  3. https://meshb.nlm.nih.gov/record/ui?ui=D054873
  4. https://www.einpresswire.com/article/688184777/incretin-based-drugs-market-to-record-remarkable-growth-projected-to-reach-usd-73-9-billion-by-2032
  5. https://www.alliedmarketresearch.com/incretin-based-drugs-market
  6. https://www.keionline.org/wp-content/uploads/KEI-BN-2024-1.pdf
  7. https://www.fda.gov/drugs/information-drug-class/incretin-mimetic-drugs-type-2-diabetes
  8. https://www.zionmarketresearch.com/report/incretin-based-drugs-market
  9. https://patents.google.com/patent/WO2019125938A1/en
  10. https://pmc.ncbi.nlm.nih.gov/articles/PMC11457043/
  11. https://www.coherentmarketinsights.com/industry-reports/incretin-mimetics-market
  12. https://patents.google.com/patent/WO2019125929A1/en
  13. https://pubmed.ncbi.nlm.nih.gov/37505513/
  14. https://www.databridgemarketresearch.com/reports/global-incretin-mimetics-market
Last updated: 2025-03-27

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