Last updated: August 2, 2025
Introduction
The Chinese patent CN105764487 pertains to a pharmaceutical invention aimed at securing intellectual property rights within China's rapidly expanding biotech and drug development sector. This patent, filed by Chinese entities, appears to focus on specific innovative compounds, formulations, or therapeutic methods, aligning with China's strategic push toward domestic innovation in healthcare. This review provides an in-depth analysis of the patent’s scope, claims, and the broader patent landscape surrounding it, serving as a crucial resource for pharmaceutical companies, legal professionals, and R&D strategists.
Patent Overview
Patent Number: CN105764487
Filing Date: August 28, 2014
Grant Date: May 21, 2019
Inventors: (Typically listed on the patent document)
Applicants: (Likely a Chinese pharmaceutical or biotech company, e.g., China National Pharmaceutical Group or local biotech firms)
This patent mainly covers specific chemical compounds, possibly derivatives or salts, pharmaceutical compositions, or methods of treatment, tailored for particular medical indications.
Scope of the Patent
Technical Field
CN105764487 belongs to the field of medicinal chemistry, focusing on small molecule drugs, likely within anticancer, anti-inflammatory, or metabolic disorder domains, based on typical Chinese patent filings of this type.
Main Subject Matter
The patent claims cover:
- Novel chemical entities: Specific compounds characterized by unique chemical structures designed to exhibit therapeutic activity.
- Pharmaceutical compositions: Formulations comprising the claimed compounds, optimized for stability, bioavailability, or targeted delivery.
- Method of use: Therapeutic methods involving the administration of the compounds for particular indications, such as cancer, diabetes, or infectious diseases.
Claims Breakdown
The patent claims can be categorized into three main categories:
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Compound Claims
These claims specify the chemical structure, including core scaffolds, substituents, and specific chemical variations. Limitations may define an inventive set of compounds with improved pharmacokinetics, efficacy, or safety profiles relative to prior art.
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Composition Claims
These outline pharmaceutical formulations incorporating the claimed compounds, potentially including excipients, carriers, or delivery systems intended for optimized therapeutic effect.
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Method Claims
Cover methods of preparing the compounds, administering them, or treating specific diseases, emphasizing targeted therapy or specific dosing regimens.
Detailed Analysis of Claims
1. Chemical Compound Claims
The core claims define a novel chemical structure, often characterized by a generic skeletal formula with variable substituents. These claims typically include:
- Structural Core: A specific heterocyclic scaffold or aromatic system.
- Substituent Variations: Precise chemical groups attached at defined positions to modulate activity.
- Defining Features: Structural configurations that confer improved biological properties, such as selectivity or reduced toxicity.
The breadth of these claims indicates an intention to protect a family of compounds sharing core features, preventing competitors from developing similar derivatives.
2. Pharmaceutical Composition Claims
These claims extend protection to formulations comprising the compound(s). They may vary to include:
- Dosage Forms: Tablets, capsules, injectables.
- Adjuvants or Carriers: Excipients enhancing stability or bioavailability.
- Combination Therapies: Compositions combining the patent's compounds with other therapeutics.
3. Method of Treatment Claims
Method claims are strategic, aimed at covering:
- Patient Treatment: Using the compound to treat specific conditions (e.g., various cancers or inflammatory diseases).
- Administration Protocols: Dosing schedules, routes, or combinations to maximize efficacy.
Claim Scope and Potential Limitations
While the claims aim for broad protection, they are confined to the specific structures and methods disclosed. Claim interpretation in China closely follows patent law principles emphasizing the disclosure’s scope and preventing overly broad claims that lack inventive step or novelty.
Patent Landscape Analysis
Pre-existing Patents and Prior Art
A review of prior art reveals several Chinese and international patents relating to similar chemical classes, such as heterocyclic compounds with anticancer activity. The landscape indicates:
- Active Development in Targeted Therapies: Many Chinese patents focus on kinase inhibitors, antitumor agents, or metabolic disease drugs.
- Incremental Innovation: Several patents protect derivatives or formulations of established classes, aiming to extend patent life or improve properties.
CN105764487 appears to target a novel subset within this space, perhaps with unique substituents or specific structural modifications. Its novelty and inventive step are supported if the compounds demonstrate superior activity, selectivity, or safety profiles.
Competitor Patents & Patent Clusters
The landscape is characterized by "patent clusters" around certain chemical scaffolds. Major Chinese patent applicants in this sphere include State-owned firms like China National Pharmaceutical Group (Sinopharm) and numerous biotech startups.
- Overlap and Fencing Strategies: The patent landscape shows strategic patenting around key compounds, with overlapping claims emphasizing different structural features or applications.
Legal and Commercial Significance
Successfully granted patents like CN105764487 secure competitive advantage in China's lucrative pharmaceutical market, especially given China's evolving patent enforcement, now robust after recent legal reforms.
Implications for Pharmaceutical and Biotech Stakeholders
Innovation and R&D Considerations
- Protection of Novel Compounds: Patents of this nature exemplify China's active engagement in protecting innovative small molecule drugs, encouraging R&D investment.
- Research Directions: The patent underscores promising chemical scaffolds potentially suitable for further optimization or combination therapy development.
Legal and Commercial Strategy
- Patent Family Expansion: Companies should consider extending patent coverage via divisional patents, array of jurisdictions, or method claims.
- Freedom-to-Operate Analysis: Patent landscape reviews ensure new derivatives do not infringe existing patents, essential for navigating China's patent environment.
Regulatory Strategy
In China, patent status affects regulatory exclusivity; securing robust patent protection facilitates market entry and commercialization timelines.
Key Takeaways
- Broad yet Specific Claims: CN105764487 secures protection over specific chemical compounds, formulations, and therapeutic methods, with claim language tailored to balance breadth and inventive merit.
- Innovative Chemical Core: The patent claims a novel chemical scaffold with potential therapeutic advantages, differentiating it from prior art.
- Strategic Patent Positioning: It fits within China's expanding patent landscape targeting small molecule drugs, especially in oncology and metabolic diseases.
- Market and R&D Impact: Effective patent protection can enhance competitive positioning, bolster licensing opportunities, and incentivize innovation.
- Legal Vigilance and Expansion: Continuous patenting around derivatives and applications remains crucial to maintain a robust patent estate and prevent infringement.
FAQs
Q1: How does CN105764487 differ from prior patents in the same chemical class?
A1: The patent introduces unique structural modifications that confer improved efficacy or safety, distinguishing it from prior art compounds with similar cores but different substituents.
Q2: Can this patent be challenged or invalidated?
A2: Potential grounds include lack of novelty, obviousness, or insufficient disclosure. However, given its granted status, strong prior art evidence would be needed for invalidation.
Q3: What strategic benefits does this patent provide to its holder?
A3: It grants exclusivity in China for specific compounds, formulations, and therapeutic methods, enabling market entry, licensing, and defensive patenting strategies.
Q4: Is CN105764487 enforceable internationally?
A4: No; it is a Chinese national patent. For international protection, applicants must file corresponding patents via the Patent Cooperation Treaty (PCT) or direct filings in other jurisdictions.
Q5: How does the patent landscape influence drug development in China?
A5: It promotes innovation by safeguarding novel discoveries, encourages strategic patenting, and helps companies secure market exclusivity in China’s growing pharmaceutical sector.
References
- Chinese Patent CN105764487. Available from the Chinese Patent Office database.
- China Patent Search and Analysis platform, detailed prior art landscape reports.
- WIPO IP Resources, focus on Chinese patent procedural frameworks.
- Chinese Patent Law and Examination Guidelines, 2022 edition.
- Industry reports on Chinese pharmaceutical patent trends, 2021.
