Make Better Decisions - Finding and Evaluating Generic and Branded Drug Market Entry Opportunities

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Finding and Evaluating Generic and Branded Drug Market Entry Opportunities

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Last Updated: December 12, 2019

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Captopril - Generic Drug Details

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What are the generic sources for captopril and what is the scope of patent protection?

Captopril is the generic ingredient in seven branded drugs marketed by Par Pharm, Acp Nimble, Apotex, Apothecon, Boscogen, Dava Pharms Inc, Egis Pharms, G And W Labs Inc, Hikma Intl Pharms, Mylan, Oxford Pharms, Prinston Inc, Purepac Pharm, Sandoz, Teva, Watson Labs, Wockhardt Ltd, Yaopharma Co Ltd, Ivax Sub Teva Pharms, and Vintage Pharms Llc, and is included in thirty NDAs. Additional information is available in the individual branded drug profile pages.

There are fifteen drug master file entries for captopril. Fifteen suppliers are listed for this compound.

Drug Prices for captopril

See drug prices for captopril

Recent Clinical Trials for captopril

Identify potential brand extensions & 505(b)(2) entrants

SponsorPhase
Wuhan UniversityPhase 2
Centro Neurológico de Pesquisa e Reabiitação, BrazilEarly Phase 1
Tanta UniversityN/A

See all captopril clinical trials

Pharmacology for captopril
Medical Subject Heading (MeSH) Categories for captopril
Synonyms for captopril
(-)-Captopril
((S)-3-mercapto-2-methylpropanoyl)-L-proline
(2S)-1-((2S)-2-methyl-3-sulfanylpropanoyl)pyrrolidine-2-carboxylic acid
(2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline
(2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
(S)-1-((S)-3-mercapto-2-methylpropanoyl)pyrrolidine-2-carboxylic acid
(S)-1-(3-Mercapto-2-methyl-1-oxo-propyl)-L-proline
(S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline
[2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline
1-((2S)-2-Methyl-3-sulfanylpropanoyl)-L-proline #
1-((2S)-3-Mercapto-2-methylpropionyl)-L-proline
1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline
1-(D-3-Mercapto-2-methyl-1-oxopropyl)-L-proline (S,S)
1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-L-proline
1-[(2S)-3-Mercapto-2-methylpropionyl]- L-proline
1-[(2s)-3-mercapto-2-methylpropionyl]-l-proline
1-[(S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline
1-Pyrrolidinecarboxylic acid, 1-(D-3-mercapto-2-methyl-1-propionyl)-, L-(S,S)-
138452-88-7
1j37
225661-74-5
3-Mercapto-2-methylpropionyl-proline
54254-EP2269989A1
54254-EP2270011A1
54254-EP2272841A1
54254-EP2277879A1
54254-EP2287165A2
54254-EP2287166A2
54254-EP2292620A2
54254-EP2295406A1
54254-EP2298742A1
54254-EP2298772A1
54254-EP2298776A1
54254-EP2298779A1
54254-EP2301923A1
54254-EP2301931A1
54254-EP2301936A1
54254-EP2305219A1
54254-EP2305648A1
54254-EP2308562A2
54254-EP2308839A1
571C862
62571-86-2
70903-77-4
9G64RSX1XD
AB00052156_17
AB00052156_18
AB00052156-16
AB0007072
AB04252
AB2000455
AC-12047
AC1L2B4L
AC1Q29GZ
AC1Q5R48
Acediur
Aceplus
Acepress
Acepril
AKOS005622581
Alopresin
Apopril
Apopril (TN)
Asisten
BBL033600
BC203925
BCP9000485
BDBM21642
BIM-0050290.0001
BPBio1_000063
BRD-K54529596-001-04-0
BRD-K54529596-001-15-6
BSPBio_000057
BSPBio_002976
C 4042
C06867
C9H15NO3S
Capoten
Capoten (TN)
Capozide (Salt/Mix)
Captolane
Captopril (Capoten)
Captopril (JP17/USP/INN)
Captopril [USAN:INN:BAN:JAN]
Captopril [USAN:USP:INN:BAN:JAN]
Captopril for system suitability, European Pharmacopoeia (EP) Reference Standard
Captopril, >=98% (HPLC), powder
Captopril, 98%
Captopril, British Pharmacopoeia (BP) Reference Standard
Captopril, European Pharmacopoeia (EP) Reference Standard
Captopril, meets USP testing specifications
Captopril, Pharmaceutical Secondary Standard; Certified Reference Material
Captopril, United States Pharmacopeia (USP) Reference Standard
Captopril,(S)
Captoprilum
Captoprilum [INN-Latin]
Captopryl
Captoril
Captril
CCG-39104
Cesplon
CHEBI:3380
CHEMBL1560
component of Acezide (Salt/Mix)
component of Captea (Salt/Mix)
component of Ecazide (Salt/Mix)
CPD000059061
CS-2425
D-2-Methyl-3-mercaptopropanoyl-L-proline
D-3-Mercapto-2-methylpropanoyl-L-proline
D-3-Mercapto-2-methylpropionylproline
D00251
DB01197
Dilabar
DivK1c_000208
DSSTox_CID_17197
DSSTox_GSID_37197
DSSTox_RID_79306
DTXSID1037197
EI-213
EINECS 263-607-1
Epitope ID:114065
EU-0100302
FAKRSMQSSFJEIM-RQJHMYQMSA-N
Farcopril
FT-0082749
Garranil
Garranil (discontinued)
GTPL5158
Hipertil
HMS1921C12
HMS2089P19
HMS2092I12
HMS2095C19
HMS2233I04
HMS3259G10
HMS3260N06
HMS3712C19
HMS500K10
HSDB 6527
HY-B0368
Hypertil
Hypopress
IDI1_000208
Isopresol
J10167
KBio1_000208
KBio2_001168
KBio2_003736
KBio2_006304
KBio3_002196
KBioGR_001321
KBioSS_001168
KM0635
KS-00000XHT
KS-5025
L-?Proline, 1-?[(2S)?-?3-?mercapto-?2-?methyl-?1-?oxopropyl]?-
L-Captopril
L-Proline, 1-((2S)-3-mercapto-2-methyl-1-oxopropyl)-
L-Proline, 1-(3-mercapto-2-methyl-1-oxopropyl)-, (S)-
L-Proline, 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-
Lopac-C-4042
Lopac0_000302
Lopirin
Lopirin [Switzerland]
Lopril
LP00302
LS-137465
MCULE-1716939647
MFCD00168073
MLS000069484
MLS001076488
MolPort-001-794-639
N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline
NC00554
NCGC00015235-01
NCGC00015235-02
NCGC00023654-03
NCGC00023654-04
NCGC00023654-05
NCGC00023654-06
NCGC00023654-07
NCGC00023654-08
NCGC00023654-09
NCGC00023654-10
NCGC00023654-11
NCGC00023654-13
NCGC00260987-01
NINDS_000208
Novocaptopril
NSC-757419
NSC757419
Opera_ID_1041
Pharmakon1600-01500682
Prestwick_103
Prestwick3_000019
s2051
SA 333
SAM002564201
SBB017523
SBI-0050290.P004
SCHEMBL4
SMP1_000056
SMR000059061
SPBio_001022
Spectrum_000688
SPECTRUM1500682
Spectrum2_001211
Spectrum3_001388
Spectrum4_000811
Spectrum5_001587
SQ 14,225
SQ 14225
SQ-14,225
SQ-14,534
SQ-14225
SQ-14534
SQ14534
SR-01000000039
SR-01000000039-2
SR-01000075603
SR-01000075603-1
SR-01000075603-3
ST079562
STK802012
Tenosbon
Tensiomin
Tensobon
Tensoprel
Tox21_110890
Tox21_110890_1
Tox21_500302
UNII-9G64RSX1XD
UPCMLD-DP003
UPCMLD-DP003:001
X8Z
Z2786051697
Zapto
ZINC57001
Paragraph IV (Patent) Challenges for CAPTOPRIL
Tradename Dosage Ingredient NDA Submissiondate
CAPOTEN TABLET;ORAL captopril 018343

US Patents and Regulatory Information for captopril

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Mylan CAPTOPRIL captopril TABLET;ORAL 074434-004 Feb 13, 1996 AB RX No Yes   Start Trial   Start Trial   Start Trial
Yaopharma Co Ltd CAPTOPRIL captopril TABLET;ORAL 074363-003 Nov 9, 1995 DISCN No No   Start Trial   Start Trial   Start Trial
Par Pharm CAPOTEN captopril TABLET;ORAL 018343-003 Approved Prior to Jan 1, 1982 DISCN Yes No   Start Trial   Start Trial   Start Trial
Acp Nimble CAPTOPRIL AND HYDROCHLOROTHIAZIDE captopril; hydrochlorothiazide TABLET;ORAL 074827-003 Dec 29, 1997 DISCN No No   Start Trial   Start Trial   Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Expired US Patents for captopril

Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration
Par Pharm CAPOTEN captopril TABLET;ORAL 018343-004 Jun 13, 1995   Start Trial   Start Trial
Par Pharm CAPOTEN captopril TABLET;ORAL 018343-001 Approved Prior to Jan 1, 1982   Start Trial   Start Trial
Par Pharm CAPOTEN captopril TABLET;ORAL 018343-004 Jun 13, 1995   Start Trial   Start Trial
Par Pharm CAPOTEN captopril TABLET;ORAL 018343-003 Approved Prior to Jan 1, 1982   Start Trial   Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >Patent No. >Patent Expiration

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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.