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Thiotepa - Generic Drug Details

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What are the generic drug sources for thiotepa and what is the scope of thiotepa patent protection?

Thiotepa is the generic ingredient in three branded drugs marketed by Immunex, Dr Reddys Labs Ltd, Fresenius Kabi Usa, Jiangsu Hengrui Med, Teva Parenteral, West-ward Pharms Int, and Adienne Sa, and is included in eight NDAs. Additional information is available in the individual branded drug profile pages.

There are eleven drug master file entries for thiotepa. Four suppliers are listed for this compound.

Summary for thiotepa

US Patents:	0
Tradenames:	3
Applicants:	7
NDAs:	8
Drug Master File Entries:	11
Suppliers / Packagers:	4
Bulk Api Vendors:	72
Clinical Trials:	182
Patent Applications:	7,549
Formulation / Manufacturing:	see details
Drug Prices:	Drug price trends for thiotepa
DailyMed Link:	thiotepa at DailyMed

Pharmacology for thiotepa

Drug Class	Alkylating Drug
Mechanism of Action	Alkylating Activity

Medical Subject Heading (MeSH) Categories for thiotepa

Antineoplastic Agents, Alkylating

Myeloablative Agonists

Synonyms for thiotepa

1-(DI(1-AZIRIDINYL)PHOSPHOROTHIOYL)AZIRIDINE

1-[Di(1-aziridinyl)phosphorothioyl]aziridine #

1,1,1-phosphorothioyltriaziridine

1,1',1''-Phosphinothioylidynetrisaziridine

1,1',1''-phosphorothioyltriaziridine

1,1''-Phosphinothioylidynetrisaziridine

145T452

1631739-26-8

24126-EP2272827A1

24126-EP2272832A1

24126-EP2275420A1

24126-EP2280012A2

24126-EP2292615A1

24126-EP2295055A2

24126-EP2295416A2

24126-EP2295426A1

24126-EP2295427A1

24126-EP2298748A2

24126-EP2298764A1

24126-EP2298765A1

24126-EP2298768A1

24126-EP2298778A1

24126-EP2301928A1

24126-EP2305642A2

24126-EP2308833A2

24126-EP2311453A1

24126-EP2314590A1

4-20-00-00052 (Beilstein Handbook Reference)

52-24-4

639-23-6

85177-92-0

905Z5W3GKH

A828998

AB00052346_07

AB00052346-06

AB0006704

AB2000286

AC1L1KDQ

AI 3-24916

AI3-24916

AKOS005267118

AN-41625

ANW-58232

AOB5373

ARONIS24177

AS-16885

Aziridine, 1,1,1"-phosphinothioylidynetris-

Aziridine, 1,1',1''-phosphinothioylidynetris-

Aziridine,1,1',1'-phosphinothioylidynetris-

AZIRIDINE,1,1',1''-PHOSPHINOTHIOYLIDYNETRIS-

Aziridine,1',1''-phosphinothioylidynetris-

BCP04110

BDBM50418086

BIDD:GT0127

BRD-K09631521-001-05-7

BRN 0145978

BSPBio_003188

C07641

C6H12N3PS

CAS-52-24-4

CBC 806495

CCG-39776

CCRIS 586

CHEBI:9570

CHEMBL671

CS-3119

CTK8B7696

D00583

DB04572

DivK1c_000817

DSSTox_CID_1339

DSSTox_GSID_21339

DSSTox_RID_76093

DTXSID0021339

EINECS 200-135-7

FOCVUCIESVLUNU-UHFFFAOYSA-N

FT-0082517

FT-0600281

GC10080

Girostan

GTPL7622

HMS1922A14

HMS2093E05

HMS2232P17

HMS3372D10

HMS502I19

HSDB 3258

HY-17574

I09-1625

IDI1_000817

KB-81272

KBio1_000817

KBio2_002169

KBio2_004737

KBio2_007305

KBio3_002688

KBioGR_000815

KBioSS_002169

KS-000010LT

KSC917M9N

Ledertepa

LS-170

MCULE-5478761622

MFCD00145452

MLS001333083

MLS001333084

MLS002207150

MLS003389372

MLS006009972

MolPort-001-783-551

N,N',N''-Tri-1,2-et hanediylthiophosphoramide

N,N',N''-Tri-1,2-ethanediylphosphorothioic triamide

N,N',N''-Tri-1,2-ethanediylthiophosphoramide

N,N',N''-Triethylenephosphorothioic triamide

N,N',N''-Triethylenethiophosphamide

N,N',N''-Triethylenethiophosphoramide

N,N',N''-Triethylenethiophosphortriamide

N,N',N"-Triethylenethiophosphamide

N,N',N"-Triethylenethiophosphoramide

N,N''-Tri-1,2-ethanediylphosphorothioic triamide

N,N''-Tri-1,2-ethanediylthiophosphoramide

N,N''-Triethylenephosphorothioic triamide

N,N''-Triethylenethiophosphamide

N,N''-Triethylenethiophosphoramide

NCGC00095042-01

NCGC00095042-02

NCGC00095042-03

NCGC00095042-04

NCGC00095042-05

NCGC00095042-06

NCGC00095042-07

NCGC00095042-08

NCGC00095042-09

NCI-C01649

NCI60_013117

NINDS_000817

NSC 6396

NSC-6396

NSC-758455

NSC6396

NSC758455

Oncotepa

Oncothio-tepa

Oncotiotepa

Pharmakon1600-01503324

Phosphine sulfide, tris(1-aziridinyl)-

Phosphoric tri(ethyleneamide)

Phosphorothioic acid triethylenetriamide

PHOSPHOROTHIOIC TRI(ETHYLENEAMIDE)

Phosphorothioic triamide, N,N',N''-tri-1,2-ethanediyl-

Phosphorothioic triamide, N,N',N''-triethylene

Phosphorothioic triamide, N,N',N''-triethylene-

Phosphorothioic triamide, N,N',N"-triethylene-

Phosphorothioic triamide,N',N''-tri-1,2-ethanediyl-

Phosphorothioic triamide,N',N''-triethylene

Q-201826

RL03925

RTR-018556

RW2156

SBI-0051814.P002

SC-27282

SCHEMBL4760

SK 6882

SMR000058542

SPBio_001434

Spectrum_001689

SPECTRUM1503324

Spectrum2_001557

Spectrum3_001594

Spectrum4_000208

Spectrum5_001641

SR-05000001855

SR-05000001855-1

SR-05000001855-5

Stepa

tepadina

Tepadina (TN)

TESPA

Tespamin

Tespamine

Thio-Tep

THIO-TEPA

Thio-tepa S

Thio-TEPA, 98%, solid

Thiofozil

Thiophosphamide

Thiophosphamidum

THIOPHOSPHORAMIDE

Thiophosphoramide, N,N',N'' -triethylene-

Thiophosphoramide, N,N',N''-tri-1,2-ethanediyl-

Thiophosphoramide, N,N',N''-triethylene-

Thiophosphoramide, N,N',N"-triethylene-

Thiophosphoramide,N',N'' -triethylene-

Thiophosphoramide,N',N''-tri-1,2-ethanediyl-

THIOPHOSPHRAMIDE,THIO-TEPA

Thioplex

Thioplex (TN)

Thioplex (TN) (Immunex)

Thiotef

Thiotepa (JAN/USP/INN)

Thiotepa [USAN:INN:BAN:JAN]

Thiotepa [USP:INN:BAN:JAN]

Thiotepa, United States Pharmacopeia (USP) Reference Standard

Thiotepum

Thiotepum [INN-Latin]

Thiotriethylenephosphoramide

Tifosyl

TIO TEF

Tio-tef

Tiofosfamid

Tiofosyl

Tiofosyl;Tiofosfamid;Triethylenethiophosphoramide;Thioplex

Tiofozil

Tiotepa

Tiotepa [INN-Spanish]

Tox21_111399

Tox21_400065

TR-018556

Tri-1-aziridinylphosphine sulfide

Tri(aziridin-1-yl)phosphine sulfide

Tri(ethyleneimino)thiophosphoramide

Triaziridinylphosphine sulfide

Triethylene thiophosphoramide

Triethylenethiop hosphoramide

Triethylenethiophosphoramide

Triethylenethiophosphorotriamide

tris(1-aziridinyl)-sulfanylidenephosphorane

Tris(1-aziridinyl)phosphine sulfide

Tris(1-aziridinyl)phosphine sulphide

tris(aziridin-1-yl)-$l;{5}-phosphanethione

tris(aziridin-1-yl)-lambda-phosphanethione

TRIS(AZIRIDIN-1-YL)-LAMBDA(5)-PHOSPHANETHIONE

tris(aziridin-1-yl)-lambda5-phosphanethione

tris(aziridin-1-yl)-sulfanylidene-

tris(aziridin-1-yl)-sulfanylidene-$l^{5}-phosphane

tris(aziridin-1-yl)-sulfanylidenephosphorane

tris(aziridin-1-yl)-thioxo-$l^{5}-phosphane

Tris(aziridinyl)-phosphine sulfide (thio-tepa)

Tris(aziridinyl)phosphine sulfide

Tris(ethylenimino)thiophosphate

TSPA

UNII-905Z5W3GKH

WLN: T3NTJ APS&- AT3NTJ&- AT3NTJ

WR 45312

WR-45312

Y0223

Z-0841

Z2574360269

ZINC1530867

US Patents and Regulatory Information for thiotepa

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Jiangsu Hengrui Med	THIOTEPA	thiotepa	INJECTABLE;INJECTION	209150-001	May 4, 2018	AP	RX	No	No
Fresenius Kabi Usa	THIOTEPA	thiotepa	INJECTABLE;INJECTION	075698-001	Sep 20, 2001		DISCN	No	No
Immunex	THIOPLEX	thiotepa	INJECTABLE;INJECTION	020058-001	Dec 22, 1994		DISCN	Yes	No
Adienne Sa	TEPADINA	thiotepa	POWDER;INTRAVENOUS	208264-002	Jan 26, 2017		RX	Yes	Yes
Immunex	THIOTEPA	thiotepa	INJECTABLE;INJECTION	011683-001	Approved Prior to Jan 1, 1982		DISCN	No	No