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TEPADINA Drug Profile

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When do Tepadina patents expire, and when can generic versions of Tepadina launch?

Tepadina is a drug marketed by Adienne Sa and is included in one NDA.

The generic ingredient in TEPADINA is thiotepa. There are eleven drug master file entries for this compound. Five suppliers are listed for this compound. Additional details are available on the thiotepa profile page.

US ANDA Litigation and Generic Entry Outlook for Tepadina

A generic version of TEPADINA was approved as thiotepa by WEST-WARD PHARMS INT on April 2^nd, 2001.

Summary for TEPADINA

US Patents:	0
Applicants:	1
NDAs:	1
Suppliers / Packagers:	1
Bulk Api Vendors:	79
Clinical Trials:	10
Patent Applications:	8,204
Formulation / Manufacturing:	see details
DailyMed Link:	TEPADINA at DailyMed

Recent Clinical Trials for TEPADINA

Identify potential brand extensions & 505(b)(2) entrants

Sponsor	Phase
University of Birmingham	Phase 3
National Heart, Lung, and Blood Institute (NHLBI)	Phase 2
Fred Hutchinson Cancer Research Center	Phase 2

See all TEPADINA clinical trials

Pharmacology for TEPADINA

Drug Class	Alkylating Drug
Mechanism of Action	Alkylating Activity

Synonyms for TEPADINA

1-[Di(1-aziridinyl)phosphorothioyl]aziridine #

1,1',1''-Phosphinothioylidynetrisaziridine

1,1',1''-phosphorothioyltriaziridine

1,1',1''-Phosphorothioyltris(aziridine)

1,1''-Phosphinothioylidynetrisaziridine

145T452

24126-EP2272827A1

24126-EP2272832A1

24126-EP2275420A1

24126-EP2280012A2

24126-EP2292615A1

24126-EP2295055A2

24126-EP2295416A2

24126-EP2295426A1

24126-EP2295427A1

24126-EP2298748A2

24126-EP2298764A1

24126-EP2298765A1

24126-EP2298768A1

24126-EP2298778A1

24126-EP2301928A1

24126-EP2305642A2

24126-EP2308833A2

24126-EP2311453A1

24126-EP2314590A1

4-20-00-00052 (Beilstein Handbook Reference)

52-24-4

905Z5W3GKH

A828998

AB00052346_07

AB00052346-06

AB0006704

AB2000286

AI 3-24916

AI3-24916

AKOS005267118

ANW-58232

AOB5373

ARONIS24177

AS-16885

Aziridine, 1,1,1"-phosphinothioylidynetris-

Aziridine, 1,1',1''-phosphinothioylidynetris-

Aziridine,1,1',1'-phosphinothioylidynetris-

AZIRIDINE,1,1',1''-PHOSPHINOTHIOYLIDYNETRIS-

Aziridine,1',1''-phosphinothioylidynetris-

BCP04110

BDBM50418086

BIDD:GT0127

BRD-K09631521-001-05-7

BRN 0145978

BSPBio_003188

C07641

C6H12N3PS

CAS-52-24-4

CBC 806495

CCG-39776

CCRIS 586

CHEBI:9570

CHEMBL671

CS-3119

CTK8B7696

D00583

DB04572

DivK1c_000817

DSSTox_CID_1339

DSSTox_GSID_21339

DSSTox_RID_76093

DTXSID0021339

EINECS 200-135-7

FOCVUCIESVLUNU-UHFFFAOYSA-N

FT-0082517

FT-0600281

GC10080

Girostan

GTPL7622

HMS1922A14

HMS2093E05

HMS2232P17

HMS3372D10

HMS502I19

HSDB 3258

HY-17574

IDI1_000817

KBio1_000817

KBio2_002169

KBio2_004737

KBio2_007305

KBio3_002688

KBioGR_000815

KBioSS_002169

KS-000010LT

KSC917M9N

Ledertepa

LS-170

MCULE-5478761622

MFCD00145452

MLS001333083

MLS001333084

MLS002207150

MLS003389372

MLS006009972

N,N',N''-Tri-1,2-et hanediylthiophosphoramide

N,N',N''-Tri-1,2-ethanediylphosphorothioic triamide

N,N',N''-Tri-1,2-ethanediylthiophosphoramide

N,N',N''-Triethylenephosphorothioic triamide

N,N',N''-Triethylenethiophosphamide

N,N',N''-Triethylenethiophosphoramide

N,N',N''-Triethylenethiophosphortriamide

N,N',N"-Triethylenethiophosphamide

N,N',N"-Triethylenethiophosphoramide

N,N''-Tri-1,2-ethanediylphosphorothioic triamide

N,N''-Tri-1,2-ethanediylthiophosphoramide

N,N''-Triethylenephosphorothioic triamide

N,N''-Triethylenethiophosphamide

N,N''-Triethylenethiophosphoramide

NCGC00095042-01

NCGC00095042-02

NCGC00095042-03

NCGC00095042-04

NCGC00095042-05

NCGC00095042-06

NCGC00095042-07

NCGC00095042-08

NCGC00095042-09

NCI-C01649

NCI60_013117

NINDS_000817

NSC 6396

NSC-6396

NSC-758455

NSC6396

NSC758455

Oncotepa

Oncothio-tepa

Oncotiotepa

Pharmakon1600-01503324

Phosphine sulfide, tris(1-aziridinyl)-

Phosphoric tri(ethyleneamide)

Phosphorothioic acid triethylenetriamide

Phosphorothioic triamide, N,N',N''-tri-1,2-ethanediyl-

Phosphorothioic triamide, N,N',N''-triethylene

Phosphorothioic triamide, N,N',N''-triethylene-

Phosphorothioic triamide, N,N',N"-triethylene-

Phosphorothioic triamide,N',N''-tri-1,2-ethanediyl-

Phosphorothioic triamide,N',N''-triethylene

Q-201826

Q416507

Rethio (TN)

RTR-018556

RW2156

s1775

SBI-0051814.P002

SC-27282

SCHEMBL4760

SK 6882

SMR000058542

SPBio_001434

Spectrum_001689

SPECTRUM1503324

Spectrum2_001557

Spectrum3_001594

Spectrum4_000208

Spectrum5_001641

SR-05000001855

SR-05000001855-1

SR-05000001855-5

Stepa

Tepadina (TN)

TESPA

Tespamin

Tespamine

Thio-Tep

THIO-TEPA

Thio-tepa S

Thio-TEPA, 98%, solid

Thiofozil

Thiophosphamide

Thiophosphamidum

Thiophosphoramide, N,N',N'' -triethylene-

Thiophosphoramide, N,N',N''-tri-1,2-ethanediyl-

Thiophosphoramide, N,N',N''-triethylene-

Thiophosphoramide, N,N',N"-triethylene-

Thiophosphoramide,N',N'' -triethylene-

Thiophosphoramide,N',N''-tri-1,2-ethanediyl-

Thioplex

Thioplex (TN)

Thioplex (TN) (Immunex)

Thiotef

thiotepa

Thiotepa (JAN/USP/INN)

Thiotepa (Thioplex)

Thiotepa [USAN:INN:BAN:JAN]

Thiotepa [USP:INN:BAN:JAN]

thiotepa-thioplex

Thiotepa, United States Pharmacopeia (USP) Reference Standard

Thiotepum

Thiotepum [INN-Latin]

Thiotriethylenephosphoramide

Tifosyl

TIO TEF

Tio-tef

Tiofosfamid

Tiofosyl

Tiofosyl;Tiofosfamid;Triethylenethiophosphoramide;Thioplex

Tiofozil

Tiotepa

Tiotepa [INN-Spanish]

Tox21_111399

Tox21_400065

TR-018556

Tri-1-aziridinylphosphine sulfide

Tri(aziridin-1-yl)phosphine sulfide

Tri(ethyleneimino)thiophosphoramide

Triaziridinylphosphine sulfide

Triethylene thiophosphoramide

Triethylenethiop hosphoramide

Triethylenethiophosphoramide

Triethylenethiophosphorotriamide

tris(1-aziridinyl)-sulfanylidenephosphorane

Tris(1-aziridinyl)phosphine sulfide

Tris(1-aziridinyl)phosphine sulphide

tris(aziridin-1-yl)-$l^{5}-phosphanethione

tris(aziridin-1-yl)-lambda-phosphanethione

tris(aziridin-1-yl)-lambda5-phosphanethione

tris(aziridin-1-yl)-sulfanylidene-$l^{5}-phosphane

tris(aziridin-1-yl)-sulfanylidenephosphorane

tris(aziridin-1-yl)-thioxo-$l^{5}-phosphane

Tris(aziridinyl)-phosphine sulfide (thio-tepa)

Tris(aziridinyl)phosphine sulfide

Tris(ethylenimino)thiophosphate

TSPA

UNII-905Z5W3GKH

WLN: T3NTJ APS&- AT3NTJ&- AT3NTJ

WR 45312

WR-45312

Y0223

Z-0841

Z2574360269

ZINC1530867

US Patents and Regulatory Information for TEPADINA

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Adienne Sa	TEPADINA	thiotepa	POWDER;INTRAVENOUS	208264-001	Jan 26, 2017	AP	RX	Yes	Yes
Adienne Sa	TEPADINA	thiotepa	POWDER;INTRAVENOUS	208264-002	Jan 26, 2017	AP	RX	Yes	Yes
Adienne Sa	TEPADINA	thiotepa	POWDER;INTRAVENOUS	208264-001	Jan 26, 2017	AP	RX	Yes	Yes
Adienne Sa	TEPADINA	thiotepa	POWDER;INTRAVENOUS	208264-002	Jan 26, 2017	AP	RX	Yes	Yes