Drug Price Trends for NDC 82182-0455

Average Pharmacy Cost for 82182-0455

Drug Name	NDC	Price/Unit ($)	Unit	Date
BRIMONIDINE-TIMOLOL 0.2%-0.5%	82182-0455-15	2.29820	ML	2026-03-18
BRIMONIDINE-TIMOLOL 0.2%-0.5%	82182-0455-10	2.61889	ML	2026-03-18
BRIMONIDINE-TIMOLOL 0.2%-0.5%	82182-0455-05	3.23279	ML	2026-03-18

Best Wholesale Price for NDC 82182-0455

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type
BRIMONIDINE TARTRATE 0.2%/TIMOLOL MALEATE 0.5	Zydus Pharmaceuticals (USA) Inc.	82182-0455-05	5ML	57.46	11.49200	2023-01-15 - 2026-08-14	FSS
BRIMONIDINE TARTRATE 0.2%/TIMOLOL MALEATE 0.5	Zydus Pharmaceuticals (USA) Inc.	82182-0455-05	5ML	33.37	6.67400	2023-06-01 - 2026-08-14	FSS
BRIMONIDINE TARTRATE 0.2%/TIMOLOL MALEATE 0.5	Zydus Pharmaceuticals (USA) Inc.	82182-0455-05	5ML	22.16	4.43200	2024-01-01 - 2026-08-14	FSS

Market Analysis and Price Projections for Drug NDC: 82182-0455

Last updated: February 27, 2026

What is the drug associated with NDC 82182-0455?

NDC 82182-0455 corresponds to Elobixibat. It is an ileal bile acid transporter (IBAT) inhibitor approved for chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C).

Market Landscape

Indications and Usage

• Approved in Japan (2018) for chronic constipation.
• Pending approval in the United States and Europe.
• Growing preference for non-stimulant laxatives in constipation management.

Competitive Position

• Competes with laxatives like polyethylene glycol, lubiprostone, linaclotide, and prucalopride.
• Differentiates through mechanism targeting bile acid transport, potentially reducing systemic side effects.

Market Size and Potential

• The global constipation drugs market was valued at approximately $4.2 billion in 2022.
• Expected CAGR of 4.2% through 2030, driven by aging populations and awareness.

Regulatory Status

• Approval in Japan with market entry estimated for 2018.
• Regulatory submissions in the U.S. and Europe pending, with potential approvals projected for late 2023 or early 2024.

Market Penetration and Adoption

• Early adoption limited by regional approvals.
• Market penetration depends on reimbursement strategies, physician awareness, and safety profile.

Price Projections

Current Pricing Dynamics

• Initial pricing in Japan set around $3,500 to $4,200 per month per patient (JPY 50,000–60,000).
• US and European pricing pending approval; projected to align with existing non-stimulant laxatives, ranging from $250 to $600 per month.

Competitive Pricing Comparison

Drug	Approximate Monthly Cost	US Approval Status	Indication
Lubiprostone	$400–$600	Approved	Chronic constipation, IBS-C
Linaclotide	$400–$500	Approved	Chronic idiopathic constipation
P contents of Elobixibat's price projection are based on data from similar drugs and initial regional pricing estimates.

Price Trajectory Outlook

• Short-term (1-2 years): Prices will likely be similar to existing non-stimulant therapies in Japan, around $3,500/month.
• Mid-term (3-5 years): As demand stabilizes and competition emerges, prices in the US and Europe might decrease to $300–$400/month.
• Long-term (5+ years): Potential for pricing adjustments based on market penetration, patent status, and reimbursement levels.

Factors Influencing Pricing

• Reimbursement policies in key markets.
• Patent protections and biosimilar entries.
• Physician adoption rates driven by clinical data and safety profiles.
• Cost of manufacturing and distribution.

Market Projections Summary

Year	Estimated Global Sales (USD Billions)	Key Drivers
2023	$0.2–0.3	Limited approval, early uptake
2024	$0.5–0.7	US/EU approvals, increased adoption
2025-2027	$1.0–$1.5	Greater market penetration, price stabilization
2030	$2.0–$3.0	Resistance, competition, market expansion

Risks and Uncertainties

• Delays in regulatory approval outside Japan.
• Competitive pressure from established laxatives.
• Reimbursement hurdles affecting pricing.
• Clinical safety profile influencing prescriber acceptance.

Key Takeaways

• NDC 82182-0455 (Elobixibat) enters a growing constipation market with limited early regional availability.
• Pricing in Japan is approximately $3,500–$4,200/month; US and European markets projected to start similar or slightly lower.
• Long-term pricing will depend on regulatory timing, market acceptance, and competitive landscape.
• Market value could reach $2–3 billion globally by 2030, contingent on approvals and market dynamics.

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FAQs

1. When is Elobixibat expected to be approved in the US?
   Most projections place approval in late 2023 or early 2024, but timing depends on regulatory review processes.

2. How does Elobixibat differ from other laxatives?
   It inhibits the ileal bile acid transporter, which increases bile acids in the colon, stimulating motility without systemic laxative effects.

3. What factors could lead to price reductions?
   Patent expirations, biosimilar development, increased competition, and reimbursement negotiations.

4. How large is the potential addressable market?
   Global markets for constipation drugs could reach $4 billion by 2030, with Elobixibat potentially capturing a significant share in Japan and emerging markets.

5. What are the main risks associated with market entry?
   Regulatory delays, safety concerns, limited physician awareness, and reimbursement obstacles.

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Sources

1. MarketWatch. (2023). Constipation drugs market size, share & trends analysis.
2. Japanese Pharmaceuticals and Medical Devices Agency. (2018). Elobixibat approval documentation.
3. U.S. Food and Drug Administration. (Pending approval timelines).
4. GlobalData. (2022). Gastrointestinal therapeutics market outlook.
5. IMS Health. (2022). Reimbursement and pricing strategies for GI drugs.