Patent: 4,588,585
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Summary for Patent: 4,588,585
Title: | Human recombinant cysteine depleted interferon-.beta. muteins |
Abstract: | Muteins of biologically active proteins such as IFN-.beta. and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. These muteins are made via bacterial expression of mutant genes that encode the muteins that have been synthesized from the genes for the parent proteins by oligonucleotide-directed mutagenesis. |
Inventor(s): | Mark; David F. (Danville, CA), Lin; Leo S. (Fremont, CA), Yu Lu; Shi-Da (Oakland, CA) |
Assignee: | Cetus Corporation (Emeryville, CA) |
Application Number: | 06/655,897 |
Patent Claims: | see list of patent claims |
Details for Patent 4,588,585
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Bayer Healthcare Pharmaceuticals Inc. | BETASERON | interferon beta-1b | For Injection | 103471 | 07/23/1993 | ⤷ Try a Trial | 2003-05-13 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
International Patent Family for US Patent 4,588,585
Country | Patent Number | Estimated Expiration |
---|---|---|
Austria | 33503 | ⤷ Try a Trial |
Austria | 46539 | ⤷ Try a Trial |
Austria | 61407 | ⤷ Try a Trial |
Austria | 73493 | ⤷ Try a Trial |
Australia | 2008683 | ⤷ Try a Trial |
>Country | >Patent Number | >Estimated Expiration |