Last Updated: June 25, 2026

Patent: 4,588,585

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Summary for Patent: 4,588,585

Title:	Human recombinant cysteine depleted interferon-.beta. muteins
Abstract:	Muteins of biologically active proteins such as IFN-.beta. and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. These muteins are made via bacterial expression of mutant genes that encode the muteins that have been synthesized from the genes for the parent proteins by oligonucleotide-directed mutagenesis.
Inventor(s):	Mark; David F. (Danville, CA), Lin; Leo S. (Fremont, CA), Yu Lu; Shi-Da (Oakland, CA)
Assignee:	Cetus Corporation (Emeryville, CA)
Application Number:	06/655,897
Patent Claims:	see list of patent claims

Details for Patent 4,588,585

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bayer Healthcare Pharmaceuticals Inc.	BETASERON	interferon beta-1b	For Injection	103471	July 23, 1993	4,588,585	2004-09-28
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 4,588,585

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Country	Patent Number	Estimated Expiration
Austria	33503	⤷ Start Trial
Austria	46539	⤷ Start Trial
Austria	61407	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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