Patent: 10,711,051

Summary for Patent: 10,711,051

Title:	Multivalent heteromultimer scaffold design and constructs
Abstract:	Provided herein are multifunctional heteromer proteins. In specific embodiments is a heteromultimer that comprises: at least two monomeric proteins, wherein each monomeric protein comprises at least one cargo polypeptide, attached to a transporter polypeptide, such that said monomeric proteins associate to form the heteromultimer. These therapeutically novel molecules comprise monomers that function as scaffolds for the conjugation or fusion of therapeutic molecular entities resulting in the creation of bispecific or multivalent molecular species.
Inventor(s):	Dixit; Surjit Bhimarao (Richmond, CA), D\'Angelo; Igor Edmondo Paolo (Port Moody, CA), Poon; David Kai Yuen (Richmond, CA)
Assignee:	ZYMEWORKS INC. (Vancouver, BC, CA)
Application Number:	16/180,456
Patent Claims:	see list of patent claims

Details for Patent 10,711,051

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Therapeutics Llc	ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5	albumin (human)	For Injection	101138	10/21/1942		2031-03-03
Baxalta Us Inc.	BUMINATE, FLEXBUMIN	albumin (human)	Injection	101452	03/03/1954		2031-03-03
Central Laboratory Of The Netherlands Red Cross Blood Transfusion Service	N/A	albumin (human)	Injection	101993	09/07/1979		2031-03-03
Csl Behring Ag	ALBURX	albumin (human)	Injection	102366	07/23/1976		2031-03-03
Grifols Biologicals Llc	ALBUTEIN	albumin (human)	Injection	102478	08/15/1978		2031-03-03
Instituto Grifols, S.a.	HUMAN ALBUMIN GRIFOLS	albumin (human)	Injection	103352	02/17/1995		2031-03-03
Instituto Grifols, S.a.	HUMAN ALBUMIN GRIFOLS	albumin (human)	Injection	103352	06/11/2003		2031-03-03