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Last Updated: July 5, 2020

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Patent: 8,877,456

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Summary for Patent: 8,877,456
Title:Quantification of botulinum toxin
Abstract: The invention relates to a method for determining the quantity of pre-synaptic neuromuscular blocking substance (notably botulinum toxin) contained in a sample. In one aspects, the method comprises the following steps: (i) determining the minimum voltage V.sub.m needed to induce the contraction of muscle tissue, said muscle tissue being connected to an electrical stimulator through a motor nerve and preferably immersed in an oxygenated physiological buffer containing glucose; (ii) adding the sample containing the pre-synaptic neuromuscular blocking substance; (iii) electrically stimulating, at a voltage at least equal to V.sub.m, the muscle tissue at certain time intervals; (iv) comparing the effect induced by the sample to the effect induced by a reference substance and thereby determining the quantity of the pre-synaptic neuromuscular blocking substance in the sample.
Inventor(s): Pickett; Andrew Martin (Berkshire, GB), Quirk; Robin Andrew (Nottingham, GB), France; Richard Melville (Nottingham, GB), Riccalton-Banks; Lisa Anne (Nottingham, GB)
Assignee: Ipsen Biopharm Limited (GB)
Application Number:10/545,009
Patent Claims:see list of patent claims

Details for Patent 8,877,456

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Elan Pharm MYOBLOC botulinum toxin type b VIAL 103846 001 2000-12-08   Start Trial Ipsen Biopharm Limited (GB) 2023-02-21 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 8,877,456

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