Polysaccharide-protein conjugates reversibly coupled via imine bonds
Method for preparing an oxidized polysaccharide-protein composition, by (a) oxidizing a polysaccharide with an oxidizing agent to form an oxidized polysaccharide where less than 20% of the oxidized units are comprised of alpha-hydroxy aldehyde units, (b) reacting the oxidized polysaccharide with a protein to form a composition comprising an oxidized polysaccharide-protein conjugate, and (c) maintaining the oxidized polysaccharide-protein conjugate composition by placing it in an environment where the temperature is less than 8.degree. C. The oxidized polysaccharide and the protein are conjugated via one or more imine bonds, the oxidized polysaccharide-protein composition is soluble in aqueous solvent, and the composition is capable of releasing the protein.
Adamson; Gord (Mississauga, CA), Bell; David (Mississauga, CA), Brookes; Steven (Mississauga, CA)
Therapure Biopharma Inc. (Mississauga, Ontario, CA)
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