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Last Updated: July 24, 2024

Patent: 8,663,945


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Summary for Patent: 8,663,945
Title:Methods of producing anti-TNF-alpha antibodies in mammalian cell culture
Abstract: The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.
Inventor(s): Pla; Itzcoatl A. (Worcester, MA), Matuck; Joseph C. (Worcester, MA), Fann; John C. (Shrewsbury, MA), Schulz; Christof (Ayer, MA), Roy; Nicole A. (Worcester, MA), Bruton; David F. (Enfield, CT), McIntire; James (Castro Valley, CA), Yu-Hsiang; David Chang (Solana Beach, CA), Seewoester; Thomas (Simi Valley, CA)
Assignee: AbbVie Inc (North Chicago, IL)
Application Number:13/308,075
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 8,663,945
Patent Claims:see list of patent claims

Details for Patent 8,663,945

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Abbvie Inc. HUMIRA adalimumab Injection 125057 December 31, 2002 ⤷  Sign Up 2026-09-13
Abbvie Inc. HUMIRA adalimumab Injection 125057 February 21, 2008 ⤷  Sign Up 2026-09-13
Abbvie Inc. HUMIRA adalimumab Injection 125057 April 24, 2013 ⤷  Sign Up 2026-09-13
Abbvie Inc. HUMIRA adalimumab Injection 125057 September 23, 2014 ⤷  Sign Up 2026-09-13
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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