Methods for protecting allogeneic islet transplant using soluble CTLA4 mutant molecules
The present invention is a method of inhibiting islet cell transplant rejection, particularly to treat diabetes, such as type-1 and type-2 diabetes, by administering to a subject an effective amount of a soluble CTLA4 mutant molecule. One example of a soluble CTLA4 mutant molecule is L104EA29YIg.
Larsen; Christian P. (Atlanta, GA), Pearson; Thomas C. (Atlanta, GA), Adams; Andrew B. (Atlanta, GA), Peach; Robert J. (San Diego, CA), Linsley; Peter S. (Seattle, WA), Naemura; Joseph Roy (Bellevue, WA), Bajorath; Jurgen (Bonn, DE)
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