Last Updated: November 8, 2026

Patent: 7,041,635

Summary for Patent: 7,041,635

Title:	Factor VIII polypeptide
Abstract:	The application discloses Factor VIII polypeptides comprising internal deletions of amino acids within the area of residues 741 to 1689, wherein the thrombin cleavage sites at about 741 and about 1689 are present, and a site at about 1648 is not present, as compared to human Factor VIII.
Inventor(s):	Hun-Taek Kim, In-young Song, Jae Won Choi, Jin-Wook Jang, Yong-kook Kim, Ho Soon Lee, Yung-Jue Bang, Dae-Kee Kim
Assignee:	SK Bioscience Co Ltd
Application Number:	US10/353,753
Patent Claims:	see list of patent claims

Details for Patent 7,041,635

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Wyeth Pharmaceuticals Llc	REFACTO	antihemophilic factor (recombinant)	For Injection	103779	June 27, 2001	⤷ Start Trial	2023-01-28
Wyeth Pharmaceuticals Llc	REFACTO	antihemophilic factor (recombinant)	For Injection	103779	July 6, 2001	⤷ Start Trial	2023-01-28
Csl Behring Lengnau Ag	AFSTYLA	antihemophilic factor (recombinant), single chain	For Injection	125591	May 25, 2016	⤷ Start Trial	2023-01-28
Csl Behring Lengnau Ag	AFSTYLA	antihemophilic factor (recombinant), single chain	For Injection	125591	March 31, 2017	⤷ Start Trial	2023-01-28
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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