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Last Updated: April 26, 2024

Patent: 5,677,278

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Summary for Patent: 5,677,278

Title:	Truncated keratinocyte growth factor (KGF) having increased biological activity
Abstract:	The present invention relates to a keratinocyte growth factor fragment, KGF.sub.des1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF.sub.163. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues, C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R- (SEQ ID NO: 2) of the KGF.sub.163 N-terminus. The present invention also relates to a DNA molecule encoding KGF.sub.des1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGF.sub.des1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGF.sub.des1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGF.sub.des1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes.
Inventor(s):	Gospodarowicz; Denis J. (Lafayette, CA), Masiarz; Frank R. (San Francisco, CA)
Assignee:	Chiron Corporation (Emeryville, CA)
Application Number:	08/410,941
Patent Claims:	see list of patent claims

Details for Patent 5,677,278

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Swedish Orphan Biovitrum Ab (publ)	KEPIVANCE	palifermin	For Injection	125103	12/15/2004	⤷ Try a Trial	2039-03-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 5,677,278

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Country	Patent Number	Estimated Expiration
Austria	278777	⤷ Try a Trial
Australia	681405	⤷ Try a Trial
Australia	6820894	⤷ Try a Trial
Bulgaria	100236	⤷ Try a Trial
Brazil	9407035	⤷ Try a Trial
>Country	>Patent Number	>Estimated Expiration

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