Patent: 5,677,278

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Summary for Patent: 5,677,278

Title:	Truncated keratinocyte growth factor (KGF) having increased biological activity
Abstract:	The present invention relates to a keratinocyte growth factor fragment, KGF.sub.des1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF.sub.163. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues, C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R- (SEQ ID NO: 2) of the KGF.sub.163 N-terminus. The present invention also relates to a DNA molecule encoding KGF.sub.des1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGF.sub.des1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGF.sub.des1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGF.sub.des1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes.
Inventor(s):	Gospodarowicz; Denis J. (Lafayette, CA), Masiarz; Frank R. (San Francisco, CA)
Assignee:	Chiron Corporation (Emeryville, CA)
Application Number:	08/410,941
Patent Claims:	see list of patent claims

Details for Patent 5,677,278

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Biovitrum Ab	KEPIVANCE	palifermin	INJECTABLE; INJECTION	125103	001	2004-12-15	Try a Free Trial	Chiron Corporation (Emeryville, CA)	2036-04-30	RX		company
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Number	>Approval Date	>Patent No.	>Assignee	>Estimated Patent Expiration	>Status	>Orphan	>Source

International Patent Family for US Patent 5,677,278

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Country	Patent Number	Publication Date
Austria	278777	Oct 15, 2004
Australia	681405	Aug 28, 1997
Australia	6820894	Jan 24, 1995
Bulgaria	100236	Jul 31, 1996
Brazil	9407035	Mar 12, 1996
Canada	2166278	Jan 12, 1995
>Country	>Patent Number	>Publication Date

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