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Patent: 5,677,278
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Summary for Patent: 5,677,278
| Title: | Truncated keratinocyte growth factor (KGF) having increased biological activity |
| Abstract: | The present invention relates to a keratinocyte growth factor fragment, KGF.sub.des1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF.sub.163. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues, C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R- (SEQ ID NO: 2) of the KGF.sub.163 N-terminus. The present invention also relates to a DNA molecule encoding KGF.sub.des1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGF.sub.des1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGF.sub.des1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGF.sub.des1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes. |
| Inventor(s): | Gospodarowicz; Denis J. (Lafayette, CA), Masiarz; Frank R. (San Francisco, CA) |
| Assignee: | Chiron Corporation (Emeryville, CA) |
| Application Number: | 08/410,941 |
| Patent Claims: | see list of patent claims |
Details for Patent 5,677,278
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Number | Approval Date | Patent No. | Assignee | Estimated Patent Expiration | Status | Orphan | Source |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Biovitrum Ab | KEPIVANCE | palifermin | INJECTABLE; INJECTION | 125103 | 001 | 2004-12-15 | Start Trial | Chiron Corporation (Emeryville, CA) | 2039-03-29 | RX | company | |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Number | >Approval Date | >Patent No. | >Assignee | >Estimated Patent Expiration | >Status | >Orphan | >Source |
International Patent Family for US Patent 5,677,278
| Country | Patent Number | Estimated Expiration |
|---|---|---|
| World Intellectual Property Organization (WIPO) | 9501434 | Start Trial |
| United States of America | 2004138123 | Start Trial |
| United States of America | 2005090445 | Start Trial |
| United States of America | 2009093400 | Start Trial |
| United States of America | 5773586 | Start Trial |
| United States of America | 5843883 | Start Trial |
| United States of America | 5863767 | Start Trial |
| >Country | >Patent Number | >Estimated Expiration |
