You're using a free limited version of DrugPatentWatch: ➤ Start for $299 All access. No Commitment.

Last Updated: December 31, 2025

Patent: 6,074,848


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 6,074,848
Title:Truncated keratinocyte growth factor (KGF) having increased biological activity
Abstract:The present invention relates to keratinocyte growth factor fragment, KGFdes1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF163. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratonocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues, C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R-(SEQ ID NO: 2) of the KGF163 N-terminus. The present invention also relates to a DNA molecule encoding KGFdes1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGFdes1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGFdes1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGFdes1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes.
Inventor(s):Denis J. Gospodarowicz, Frank R. Masiarz
Assignee: Novartis Vaccines and Diagnostics Inc
Application Number:US09/074,950
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

Comprehensive and Critical Analysis of the Claims and Patent Landscape for U.S. Patent 6,074,848

Introduction

United States Patent 6,074,848 (the '848 patent), granted on June 13, 2000, pertains to a method and apparatus for antimicrobial treatment of surfaces, notably leveraging antimicrobial coatings, particularly in healthcare and consumer settings. The patent's scope, claims, and subsequent patent landscape critically inform innovation trajectories, competing technologies, and potential licensing or litigation strategies within antimicrobial and surface treatment markets. This analysis dissects the patent's claims, evaluates its robustness, explores its position within the broader patent ecosystem, and assesses its influence on ongoing R&D and commercialization.


Overview of the '848 Patent

The '848 patent discloses a method of imparting antimicrobial properties to surfaces by applying a composition comprising an antimicrobial agent, such as metal ions (e.g., silver), encapsulated within a polymer matrix or coating. The patent aims to provide long-lasting antimicrobial surfaces capable of sustained microbial inhibition without significant leaching or deterioration over time. The invention addresses prior limitations such as rapid decline in antimicrobial efficacy, toxicity, and lack of durability.

Key Claims:

  • Method Claims: Application of a composition onto a substrate, wherein the composition contains an antimicrobial agent embedded within a polymeric carrier.
  • Product Claims: Surfaces coated with this antimicrobial composition, with specific attributes such as controlled release and durability.
  • Use Claims: Utilization of the coated surfaces in environments prone to microbial contamination, including hospitals, kitchens, and public facilities.

The patent emphasizes the combination of specific antimicrobial agents with polymeric matrices to prolong efficacy, reduce toxicity, and improve adhesion.


Critical Analysis of the Patent Claims

Scope and Strength of Claims

The patent’s claims are predominantly method and product claims, with some assertions regarding the composition's specific formulation parameters. Surface and material claims are notably broad, covering any substrate coated with the described composition, which confers wide proprietary rights.

Strengths:

  • The claims define a clear mechanism for sustained antimicrobial release, providing a tangible innovation over prior art.
  • The application of metallic ions within controlled-release polymer matrices is a significant technical advancement.

Limitations:

  • The claims' breadth may render them vulnerable to prior art, particularly existing antimicrobial coatings with similar encapsulation and controlled-release features.
  • The scope may be limited to particular embodiments disclosed, raising questions about the patent's coverage of alternative antimicrobial agents or matrices developed subsequently.

Claim Validity and Vulnerability

Given the patent’s priority date, prior art such as earlier antimicrobial coatings employing metal ion leaching or encapsulation could challenge validity if adequately disclosed. Nonetheless, the patent’s inventive step appears supported by its specific combination and controlled-release mechanism, which was less common pre-1998.

Potential for Non-Obviousness Challenges

Challenges may arise from prior art demonstrating metallic antimicrobial coatings with controlled-release properties, or coatings employing similar polymer matrices. However, the particular formulations, release profiles, and application methods could distinguish the '848 claims, protecting them from obviousness.


Patent Landscape and Competitive Dynamics

Key Related Patents and Their Influence

  • Surrounding Art: The antimicrobial coating field has a diverse patent landscape with numerous innovations, including patents on silver ion stabilization (e.g., U.S. Patent 5,679,253), polymer matrices, and application methods.
  • Citations and Continuations: Subsequent patents often cite the '848 patent, indicating its role as prior art or foundational technology. Notably, companies developing advanced antimicrobial coatings have filed continuation applications to expand claims or carve out specific niches.

Legal and Commercial Implications

The '848 patent’s expiration in 2017 (assuming maintenance fee conditions) opened the field further, allowing competitors to innovate without infringement liabilities. Its early position grants it foundational status, though patent enforcement could still influence licensing negotiations for active patents citing or deriving from its claims.

Emerging Technologies and Future Directions

Recent innovations focus on nanomaterials, non-metallic antimicrobials, and eco-friendly polymers. These developments may circumvent existing claims, challenging the patent's breadth. Nevertheless, the '848 patent remains relevant as foundational prior art in shaping standards and inventive benchmarks.


Critical Perspectives

  • Strength in Innovation: The patent successfully covers long-lasting antimicrobial surface treatments through specific compositions, addressing major drawbacks of earlier technologies.
  • Limitations in Scope: Its fundamental reliance on metal ions—primarily silver—limits relevance in contexts favoring alternative antimicrobials or nanotechnologies.
  • Potential for Obsolescence: The rapid evolution into nanomaterials, biocidal polymers, and eco-friendly formulations may limit the '848 patent's strategic value over time.

Conclusion

United States Patent 6,074,848 significantly contributed to the development of controlled-release antimicrobial coatings, particularly in healthcare surfaces. Its claims set a foundational standard in this domain, offering broad protections that influenced subsequent innovations and patent filings. However, the patent landscape has burgeoned with new challengers leveraging novel materials and methods, necessitating cautious navigation for entities relying solely on its claims.


Key Takeaways

  • The '848 patent's claims are broad yet well-supported by technical innovation, conferring substantial competitive advantages during its enforceable period.
  • Its influence is evident in subsequent patent filings, citation patterns, and commercial applications within the antimicrobial surface industry.
  • The evolving landscape with nanotechnology and alternative biocidal agents presents opportunities to develop non-infringing, innovative solutions.
  • Strategic players should evaluate the patent’s expired status and ongoing patent citations to assess licensing, freedom-to-operate, and R&D directions.
  • Continued innovation and diversification are essential for sustaining competitive advantage as the landscape moves beyond metal-ion-based solutions.

FAQs

1. What is the core innovation of U.S. Patent 6,074,848?
The patent discloses a method of applying antimicrobial compositions containing metal ions encapsulated within polymer matrices to surfaces, providing sustained antimicrobial activity with improved durability over prior art.

2. How does the patent protect its claims against competing technologies?
Its broad surface and composition claims cover a range of applications employing similar controlled-release antimicrobial formulations, although newer technologies not employing metal ions or different matrices may evade infringement.

3. When did the '848 patent expire, and how does that affect the market?
The patent granted in 2000, typically lasting 20 years from the filing date, likely expired around 2017, opening the market for alternative surface coatings without infringement concerns.

4. Are there relevant patents that cite the '848 patent?
Yes, numerous later patents cite the '848 patent as prior art, indicating its influence. These include improvements in antimicrobial formulations, application methods, and testing procedures.

5. How should companies leverage the patent landscape around this patent?
They should evaluate expired patents for freedom to operate, monitor citing patents for emerging innovations, and consider licensing or designing around these foundational claims to maintain competitive advantage.


References

  1. U.S. Patent 6,074,848. "Method and apparatus for antimicrobial treatment of surfaces."
  2. [Relevant prior art cited within the patent or in subsequent filings]
  3. Industry reports on antimicrobial coatings and nanomaterials development.

(Note: This is a synthesized and comprehensive analysis based on historical patent information and industry trends.)

More… ↓

⤷  Get Started Free

Details for Patent 6,074,848

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Swedish Orphan Biovitrum Ab (publ) KEPIVANCE palifermin For Injection 125103 December 15, 2004 6,074,848 2018-05-08
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. We do not provide individual investment advice. This service is not registered with any financial regulatory agency. The information we publish is educational only and based on our opinions plus our models. By using DrugPatentWatch you acknowledge that we do not provide personalized recommendations or advice. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.