Patent: 5,656,722
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Summary for Patent: 5,656,722
Title: | A.sup.21 -, B.sup.30 - modified insulin derivatives having an altered action profile |
Abstract: | New insulin derivatives, the use thereof, and a pharmaceutical composition containing them Insulin derivatives having an isoelectric point between 5 and 8.5, or physiologically tolerated salts thereof, of the Formula II ##STR1## in which: R.sup.1 at position B1 denotes H or H-Phe; R.sup.2 at position A21 denotes a genetically encodable L-amino acid selected from the group consisting of Gly, Ala, Val, Leu, Ile, Pro, Phe, Trp, Met, Ser, Thr, Cys, Tyr, Asp, and Glu; R.sup.30 represents the residue of a neutral genetically encodable L-amino acid selected from the group consisting of Ala, Thr, and Ser; R.sup.31 represents 1, 2, or 3 neutral or basic alpha amino acids, wherein at least one of the alpha amino acids is selected from the group consisting of Arg, Lys, Hyl, Orn, Cit, and His; X represents His at position B10; and the sequences A1 to A20 and B1 to B29 in Formula II correspond to a mammalian insulin; excluding those insulin derivatives in which simultaneously: R.sup.1 at position B1 denotes Phe; and R.sup.3 is one alpha amino acid having a terminal carboxyl group. |
Inventor(s): | Dorschug; Michael (Bochum, DE) |
Assignee: | Hoechst Aktiengesellschaft (Frankfurt am Main, DE) |
Application Number: | 08/304,593 |
Patent Claims: | see list of patent claims |
Details for Patent 5,656,722
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Sanofi-aventis U.s. Llc | LANTUS | insulin glargine | Injection | 021081 | 04/20/2000 | ⤷ Try a Trial | 2014-08-12 |
Sanofi-aventis U.s. Llc | LANTUS | insulin glargine | Injection | 021081 | 04/25/2007 | ⤷ Try a Trial | 2014-08-12 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
International Patent Family for US Patent 5,656,722
Country | Patent Number | Estimated Expiration |
---|---|---|
South Africa | 898456 | ⤷ Try a Trial |
United States of America | 6100376 | ⤷ Try a Trial |
Portugal | 92220 | ⤷ Try a Trial |
Philippines | 30695 | ⤷ Try a Trial |
New Zealand | 231272 | ⤷ Try a Trial |
>Country | >Patent Number | >Estimated Expiration |