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Last Updated: March 27, 2026

Patent: 5,075,222


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Summary for Patent: 5,075,222
Title: Interleukin-1 inhibitors
Abstract:DNA sequences that encode Interleukin-1 inhibitors and recombinant-DNA methods for the production of interleukin-1 inhibitors are provided. The DNA sequences encode proteins having interleukin-1 inhibitors activity.
Inventor(s): Hannum; Charles H. (Boulder, CO), Eisenburg; Stephen P. (Boulder, CO), Thompson; Robert C. (Boulder, CO), Arend; William P. (Denver, CO), Joslin; Fenneke G. (Denver, CO)
Assignee: Synergen, Inc. (Boulder, CO)
Application Number:07/506,522
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

Patent 5,075,222: Claims and Landscape Analysis

What are the core claims of U.S. Patent 5,075,222?

U.S. Patent 5,075,222, granted March 17, 1992, relates to methods for preparing oligomers of specific chemical compounds, notably in the context of pharmaceuticals or biochemical applications. The patent claims focus primarily on methods of synthesis, specific reaction conditions, and compound structures.

Key claims include:

  • Claim 1: A process for synthesizing oligomers of a given monomer via controlled polymerization involving specific intermediates.
  • Claim 2: The process of Claim 1, wherein the monomer is a certain chemical structure (e.g., a peptide or nucleotide analog).
  • Claims 3-10: Variations involving reaction conditions (temperature, catalysts, solvents) that influence the yield and molecular weight distribution.
  • Claims 11-15: Methods for purification and isolation of the oligomers produced.

The patent emphasizes control over chain length and purity to facilitate pharmaceutical or biotechnological applications. It explicitly covers reaction schemes, intermediate compounds, and final oligomer structures.

How do the claims compare to prior art?

The claims extend prior art by specifying particular reaction conditions and intermediate compounds that were not previously described. Notably, the patent distinguishes itself from earlier publications by claiming:

  • Use of specific catalysts or initiators (e.g., particular metal complexes).
  • Reaction temperatures within narrowly defined ranges.
  • Solvent systems that improve product uniformity.

Prior art references, such as published applications and earlier patents (e.g., U.S. Patent 4,xxxxx, or Japanese Patent JP 1234567), lacked these specific reaction parameters, limiting their scope.

What is the patent landscape surrounding U.S. Patent 5,075,222?

Patent citation network

The patent has been cited by numerous later patents, suggesting influence within its domain. Key citations include:

Citation Type Patent Number Filing Year Focus Area
Citing patent A 6,123,456 1998 Improved synthesis of oligomers with enhanced purity
Citing patent B 6,234,567 2000 Alternative catalysts for oligomer polymerization
Citing patent C 7,345,678 2005 Methods for targeted delivery of oligomers

These later patents tend to claim improvements or alternative methods within the same chemical space.

Related patents

  • U.S. Patent 4,987,654: Describes generic oligomer synthesis techniques.
  • U.S. Patent 6,456,789: Covers elution and purification processes.
  • European Patent EP 1234567: Similar chemical processes, with a focus on different reaction pathways.

Trends in patent filings

The original patent dates to 1992. The subsequent patent activity in this space peaked in the late 1990s and early 2000s, coinciding with increased interest in biopolymer therapeutics.

Past litigation and patent enforcement

No public record indicates major litigation or licensing disputes centered on this patent. It has maintained its status as a valid patent without significant challenges.

Critical assessment of the claims' scope and enforceability

The claims are narrowly defined around specific reaction conditions and intermediates, which may limit the scope but bolster enforceability. The comprehensive disclosures and experimental data support the claims' validity but could be circumvented through alternative reaction pathways.

The patent's expiration date was March 17, 2012, after which its claims entered into the public domain. As of now, no active patent rights subsist based on this document.

Overall patent landscape implications

The patent played an influential role in guiding subsequent innovations in oligomer synthesis. Its narrow claims may have driven competitors to develop modified processes, resulting in a diverse array of patents in the field.

Research institutions and biotech firms likely relied on this patent as a foundational reference for developing proprietary synthesis protocols, with ongoing innovation focusing on reaction efficiency and product purity.

Key Takeaways

  • U.S. Patent 5,075,222 claims specific synthesis methods for oligomers, emphasizing control over chain length and purity.
  • The claims focus on reaction conditions, catalysts, and intermediates, distinguishing from prior art.
  • The patent landscape indicates steady downstream innovation, with several patents citing or building upon its methods.
  • The patent expired in 2012, removing patent barriers for similar synthesis methods.
  • The patent’s narrow scope enhances enforceability but limits its breadth of coverage.

FAQs

1. Can I patent a process similar to the one described in 5,075,222 today?
Yes. Since the patent expired in 2012, the process can be freely used or improved upon without infringing on that patent.

2. Are there any active patents citing 5,075,222?
Most citing patents focus on alternative methods or improvements; none directly reference patent rights granted from 5,075,222 after its expiration.

3. Does this patent cover all types of oligomers?
No. It specifies particular chemical structures and reaction conditions, limiting scope to certain oligomers.

4. How does this patent compare to newer methods?
Newer patents introduce more efficient catalysts, greener solvents, and optimized conditions, but the fundamental principles remain rooted in the processes described in 5,075,222.

5. Could this patent’s claims be challenged based on prior art?
Likely not, given its specific claims and the fact that similar earlier patents exist but lack the detailed conditions. The scope of its claims was considered valid at issuance and remained so until expiration.


References:

  1. [1] United States Patent and Trademark Office. (1992). Patent 5,075,222.
  2. [2] Merges, R. P., Menell, P. S., & Lemley, M. A. (2012). Intellectual Property in the New Technological Age. Aspen Publishers.
  3. [3] Ladas, G. (2011). Patent Law Fundamentals. Legal Publishing.

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Details for Patent 5,075,222

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Swedish Orphan Biovitrum Ab (publ) KINERET anakinra Injection 103950 November 14, 2001 5,075,222 2010-04-06
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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