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Last Updated: July 29, 2021

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Patent: 4,530,787

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Summary for Patent: 4,530,787
Title: Controlled oxidation of microbially produced cysteine-containing proteins
Abstract:Method of oxidizing reduced cysteine-containing microbially produced synthetic proteins, such as synthetic IFN-.beta. or synthetic IL-2, in a controlled manner so that the synthetic proteins have the same disulfide bridging as their native counterparts. The oxidation employs o-iodosobenzoate as oxidizing agent and is carried out in an aqueous medium at a pH at least about one-half pH unit less than the pK.sub.a of the cysteines to be oxidized, a synthetic protein concentration of less than about 5 mg/ml, and an oxidizing agent:protein mol ratio that is at least stoichiometric, provided that the oxidizing agent is in excess in the terminal portion of the reaction.
Inventor(s): Shaked; Ze\'ev (Berkeley, CA), Wolfe; Sidney N. (Richmond, CA)
Assignee: Cetus Corporation (Emeryville, CA)
Application Number:06/661,902
Patent Claims:see list of patent claims

Details for Patent 4,530,787

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Bayer Healthcare Pharms BETASERON interferon beta-1b VIAL; SUBCUTANEOUS 103471 001 1993-07-23 ⤷  Try it Free Cetus Corporation (Emeryville, CA) 2004-03-28 RX Orphan company
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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