Patent: 4,530,787
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Summary for Patent: 4,530,787
| Title: | Controlled oxidation of microbially produced cysteine-containing proteins |
| Abstract: | Method of oxidizing reduced cysteine-containing microbially produced synthetic proteins, such as synthetic IFN-.beta. or synthetic IL-2, in a controlled manner so that the synthetic proteins have the same disulfide bridging as their native counterparts. The oxidation employs o-iodosobenzoate as oxidizing agent and is carried out in an aqueous medium at a pH at least about one-half pH unit less than the pK.sub.a of the cysteines to be oxidized, a synthetic protein concentration of less than about 5 mg/ml, and an oxidizing agent:protein mol ratio that is at least stoichiometric, provided that the oxidizing agent is in excess in the terminal portion of the reaction. |
| Inventor(s): | Shaked; Ze\'ev (Berkeley, CA), Wolfe; Sidney N. (Richmond, CA) |
| Assignee: | Cetus Corporation (Emeryville, CA) |
| Application Number: | 06/661,902 |
| Patent Claims: | see list of patent claims |
Details for Patent 4,530,787
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Bayer Healthcare Pharmaceuticals Inc. | BETASERON | interferon beta-1b | For Injection | 103471 | 07/23/1993 | ⤷ Try a Trial | 2004-03-28 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
International Patent Family for US Patent 4,530,787
| Country | Patent Number | Estimated Expiration |
|---|---|---|
| Austria | 108186 | ⤷ Try a Trial |
| Austria | 196769 | ⤷ Try a Trial |
| Canada | 1233172 | ⤷ Try a Trial |
| Germany | 156354 | ⤷ Try a Trial |
| Germany | 3587873 | ⤷ Try a Trial |
| Germany | 3588226 | ⤷ Try a Trial |
| European Patent Office | 0156354 | ⤷ Try a Trial |
| >Country | >Patent Number | >Estimated Expiration |
