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Last Updated: April 19, 2024

Patent: 4,450,103

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Summary for Patent: 4,450,103

Title:	Process for recovering human IFN-.beta. from a transformed microorganism
Abstract:	A process for recovering IFN-.beta. from transformed bacteria comprising: disrupting the cell membranes of the bacteria; solubilizing the IFN-.beta. from the disruptate into an aqueous medium with a solubilizing agent such as sodium dodecyl sulfate; extracting the IFN-.beta. from the aqueous medium with 2-butanol, 2-methyl-butanol, or mixtures thereof under conditions that maintain phase separation between the aqueous meduim and the extractant; and isolating the IFN-.beta. from the extractant such as by precipitating the IFN-.beta. from an aqeous buffer mixture of the extractant by lowering the pH thereof.
Inventor(s):	Konrad; Michael W. (Alameda, CA), Lin; Leo S. (Fremont, CA)
Assignee:	Cetus Corporation (Emeryville, CA)
Application Number:	06/353,360
Patent Claims:	see list of patent claims

Details for Patent 4,450,103

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bayer Healthcare Pharmaceuticals Inc.	BETASERON	interferon beta-1b	For Injection	103471	07/23/1993	⤷ Try a Trial	2039-03-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 4,450,103

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Country	Patent Number	Estimated Expiration
Austria	20090	⤷ Try a Trial
Australia	1331783	⤷ Try a Trial
Australia	549721	⤷ Try a Trial
Canada	1187013	⤷ Try a Trial
Germany	3363647	⤷ Try a Trial
>Country	>Patent Number	>Estimated Expiration

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