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Last Updated: July 23, 2021

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Patent: 4,450,103

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Summary for Patent: 4,450,103
Title: Process for recovering human IFN-.beta. from a transformed microorganism
Abstract:A process for recovering IFN-.beta. from transformed bacteria comprising: disrupting the cell membranes of the bacteria; solubilizing the IFN-.beta. from the disruptate into an aqueous medium with a solubilizing agent such as sodium dodecyl sulfate; extracting the IFN-.beta. from the aqueous medium with 2-butanol, 2-methyl-butanol, or mixtures thereof under conditions that maintain phase separation between the aqueous meduim and the extractant; and isolating the IFN-.beta. from the extractant such as by precipitating the IFN-.beta. from an aqeous buffer mixture of the extractant by lowering the pH thereof.
Inventor(s): Konrad; Michael W. (Alameda, CA), Lin; Leo S. (Fremont, CA)
Assignee: Cetus Corporation (Emeryville, CA)
Application Number:06/353,360
Patent Claims:see list of patent claims

Details for Patent 4,450,103

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Bayer Healthcare Pharms BETASERON interferon beta-1b VIAL; SUBCUTANEOUS 103471 001 1993-07-23 ⤷  Try it Free Cetus Corporation (Emeryville, CA) 2039-03-29 RX Orphan company
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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