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Last Updated: September 18, 2020

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Patent: 4,098,645

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Summary for Patent: 4,098,645
Title: Immobilization of proteins with polyurethane polymers
Abstract:A protein which can be an enzyme is immobilized by: (a) admixing the protein and an isocyanate-capped liquid polyurethane prepolymer in the absence of water to form a resulting mixture (an intermediate product); and (b) forming the intermediate product by reacting it with water to form a polyurethane foam comprising the immobilized enzyme. When certain proteins in sufficient amount are mixed with the prepolymer in the absence of water the resultant protein prepolymer mixture will solidify to produce a solid non-foamed product containing a protein immobilized therein. Initially mixing the protein and prepolymer in the absence of water results in immobilization of a substantially greater amount of protein than when water is present.
Inventor(s): Hartdegen; Frank Joseph (Columbia, MD), Swann; Wayne Elliott (Pasadena, MD)
Assignee: W. R. Grace & Co. (New York, NY)
Application Number:05/743,035
Patent Claims:see list of patent claims

Details for Patent 4,098,645

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial W. R. Grace & Co. (New York, NY) 1996-02-24 RX search
Csl Behring Ag CARIMUNE human immunoglobulin g INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 102367 1 2009-02-10   Start Trial W. R. Grace & Co. (New York, NY) 1996-02-24 search
Csl Behring Ag PRIVIGEN human immunoglobulin g LIQUID 125201 1 2009-01-20   Start Trial W. R. Grace & Co. (New York, NY) 1996-02-24 search
Bio Products Laboratory Limited GAMMAPLEX human immunoglobulin g SOLUTION 125329 1 2017-04-07   Start Trial W. R. Grace & Co. (New York, NY) 1996-02-24 search
Csl Behring Ag HIZENTRA human immunoglobulin g LIQUID 125350 1 2020-01-01   Start Trial W. R. Grace & Co. (New York, NY) 1996-02-24 search
Adma Biologics, Inc. ASCENIV human immunoglobulin g LIQUID 125590 1 2019-04-01   Start Trial W. R. Grace & Co. (New York, NY) 1996-02-24 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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