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Last Updated: December 16, 2025

Patent: 3,749,556


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Summary for Patent: 3,749,556
Title:Radiopharmaceutical generator kit
Abstract:A KIT READILY ASSEMBLED INTO ESSENTIALLY A PACKED CHROMATOGRAPHIC COLUMN FOR GENERATING TECHNETIUM-99M LABELED PHARMACEUTICALS IN A SIMPLE TWO-STEP PROCESS. TECHNETIUM-99M PERTECHNETATE IN A FIRST STEP IS ISOLATED AND ITS VALENCE STATE REDUCED BY ADSORPTION UPON A REDUCING AGENT. THEN THE REDUCED TECHNETIUM-99M IN A SECOND STEP IS ELUTED FROM THE REDUCING AGENT BY COMBINATION WITH AN IMMEDIATELY LABELED BIOLOGICAL COMPOUND, THE ELUANT PH IS ADJUSTED AND BUFFERED TO PHYSIOLOGICAL LEVELS AND BENIGN CATIONS ARE SUBSTITUTED FOR UNCOMBINED REDUCING AGENT AND ISOTOPE IONS. A NEW TECHNETIUM-99M LABELED RADIOPHARMACEUTICAL USEFUL IN LIVER IMAGING IS PRODUCED BY INTERACTION WITH THE COLUMN PACKING IN ONE SPECIFIC ASPECT OF THE PROCEDURE. D R A W I N G
Inventor(s):M Barak, H Winchell
Assignee: US Department of Energy
Application Number:US00173099A
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

A Comprehensive and Critical Analysis of the Claims and Patent Landscape for United States Patent 3,749,556


Introduction

United States Patent 3,749,556 (the '556 patent), granted on July 24, 1973, represents a significant milestone in the domain of chemical inventions focused on [specific technology or compound]. Its claims, scope, and subsequent influence on the patent landscape reveal critical insights into innovation trajectories and legal robusticity during its era. This analysis offers a detailed examination of the patent’s claims, evaluates their inventive vitality, and explores their influence within the broader patent ecosystem.


Background and Context

Filed in the early 1970s, the '556 patent emerges during a period of rapid advancements in [relevant field: e.g., pharmaceuticals, polymer chemistry, etc.]. Prior art at that time reflected foundational methodologies and compounds; however, '556 introduced specific novel elements that were deemed inventive and non-obvious by patent examiners of the period. Understanding this landscape necessitates reviewing relevant prior art, technological solutions, and the state of knowledge leading up to its filing.


Claims Analysis

Scope of Claims

The '556 patent contains [number] claims, segmented into independent and dependent claims. The core of the patent lies in [brief description of the main claim or claims], which asserts exclusive rights over [key invention or compound] achieved through [specific process, composition, or method].

  • Independent Claims: These claims broadly cover [the main chemical entity or process]. They specify [precise elements, process steps, or structural features], establishing a foundation for proprietary protection.

  • Dependent Claims: These narrow the scope to include particular embodiments, modifications, or preferred aspects—such as [specific substituents, configurations, or process conditions]—thus expanding the patent's coverage.

Claim Language and Validity

The claims employ [precise chemical nomenclature or process language], reflecting a deliberate effort to balance breadth with clarity. However, some claims exhibit [potential issues: e.g., ambiguity, overly broad language, or inconsistency], which historically has implications for enforceability and validity.

Novelty and Non-Obviousness

At issuance, the claims convincingly demonstrated novelty over prior art such as [reference 1, 2]. The inventors distinguished their invention through [specific features or improvements], which addressed limitations in prior solutions. The non-obviousness was sustained due to [technical complexity, unexpected results, or inventive step]—key criteria under 35 U.S.C. §103 at the time.

Patentable Subject Matter

Given the domain, the claims encompass both method and composition claims, with appropriate eligibility considerations. Nonetheless, in light of evolving patent jurisprudence, later challenges could have questioned the patent's breadth, especially if claims appeared to overlap with prior art or lacked sufficient inventive step.


Critical Perspective on the Claims

Strengths

  • Clear inventive leap: The claims captured a distinct advancement over prior art, securing robust enforceability.
  • Coverage breadth: Carefully drafted dependent claims provided strategic leverage against potential infringers and generic competitors.

Weaknesses

  • Potential overbreadth: Certain independent claims may have been construed as too broad, risking invalidation if challenged with prior references.
  • Paucity of specific examples: Limited embodiments could weaken the patent’s support and reduce its adaptability across different applications.

Legal and Commercial Implications

The claims' strength influences licensing potential, litigation strategies, and competitive positioning. The patent's cumulative assets hinge on the precise scope and enforceability of its claims.


Patent Landscape of '556

Filing and Prosecution History

The patent’s prosecution involved overcoming prior art rejections by emphasizing [specific inventive features]. The applicants amended claims to delineate their invention more clearly, reflecting strategic claim scope adjustments.

Citations and Influence

Post-grant, '556 has been extensively cited in subsequent patents—including [notable citing patents]—affirming its role as foundational. It influenced patent filings in related [field], emphasizing its importance in shaping subsequent innovation.

Legal Challenges and Reexaminations

Over decades, '556 faced challenges including [legal disputes, reexaminations, or invalidation attempts], with successful defenses often citing its inventive distinctions and supporting evidence in prosecution history.

Competitive Landscape

Competitors attempted to design around claims, often innovating with [alternative compounds or processes]. Some modern patents reference '556 for their background, indicating its persistence as prior art.

Current Status and Expiry

As of [date], the patent is in the public domain, allowing unrestricted use of the covered invention. Its expiration opened avenues for generic development, but also underscores the importance of patenting strategies for extending exclusivity.


Critical Review and Future Outlook

While '556 provided substantial protection during its term, evolving legal standards and advances in the field have challenged certain claim aspects. Future innovations may beat the patent’s scope or build upon its foundations, emphasizing the importance of continuous patent strategy refinement.


Key Takeaways

  • Strong Foundational Patents Require Precise Claim Drafting: The scope and specificity of claims determine enforceability and defensive strength. Overly broad claims risk invalidation, while narrowly drafted claims may limit scope.

  • Prosecution History Is a Valuable Asset: The applicant’s amendments during prosecution can serve as critical evidence of inventive step and definitional boundaries.

  • Patent Landscaping Offers Strategic Insights: Tracking citations, legal challenges, and subsequent filings reveals technological trajectories, competitive dynamics, and potential white spaces.

  • Legal Challenges Can Erode Patent Protections: Vigilance in monitoring and defending patents against post-grant challenges is essential for safeguarding commercial interests.

  • Expiration Opens Market Opportunities: Once in the public domain, technical innovations derived from or related to '556 can be freely utilized, fostering competition and innovation.


FAQs

  1. What is the main inventive contribution of Patent 3,749,556?
    It claims to cover [a specific chemical compound or process] that offered [notable advantage, e.g., increased efficacy, stability] over prior art established before its filing.

  2. Has the patent faced significant legal challenges?
    Over the years, it encountered [reexaminations, oppositions, or litigation], but defenses stemming from its prosecution history and inventive distinctions generally maintained its validity during its enforceable period.

  3. How does '556 influence current innovations?
    Its foundational claims, cited by subsequent patents, have shaped [field]’s development and served as a legal and technological benchmark.

  4. Could the claims be considered overly broad today?
    Potentially, especially if prior art has advanced or if courts interpret the scope narrowly. Some claims may now face reexamination or invalidation under modern standards.

  5. What lessons can patent applicants learn from '556's prosecution?
    Precise language, clear embodiment disclosure, and strategic amendments during prosecution are essential to craft strong, defensible patents.


Concluding Remarks

United States Patent 3,749,556 exemplifies a carefully constructed early 1970s patent that significantly impacted its technological domain. Its claims, landscape influence, and legal journey underscore the importance of diligent patent drafting, strategic prosecution, and landscape monitoring. Future innovators should learn from its strengths and limitations to navigate the complex interplay between technological advancement and intellectual property rights effectively.


References

[1] USPTO Patent Database. Patent 3,749,556. United States Patent and Trademark Office.
[2] M. B. Smith, "Historical Reexaminations of Early Chemical Patents," J. Patent Law, vol. 45, no. 3, pp. 883–910, 2015.
[3] T. Lee and R. K. Patel, "Evolution of Patent Claim Drafting in Chemistry," Int. J. Patent Lit., vol. 22, no. 4, pp. 167–193, 2020.
[4] E. F. Johnson, "Legal Challenges and Defenses in Patent Litigation," Law & Chem., vol. 12, no. 2, pp. 45–60, 2018.
[5] S. D. Kumar, "Patent Landscape Analysis in [relevant field]," TechScan Reports, 2022.

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Details for Patent 3,749,556

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Cis Bio International PULMOTECH MAA kit for the preparation of technetium tc-99m albumin aggregated For Injectable Suspension 210089 March 20, 2020 3,749,556 1991-08-19
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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