Last Updated: May 25, 2026

Patent: 11,642,406

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Summary for Patent: 11,642,406

Title:	Compositions comprising Streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof
Abstract:	The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and/or pneumococcal diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.
Inventor(s):	Chitrananda Abeygunawardana, Yadong Adam Cui, Romulo Ferrero, Jian He, Luwy Musey, Tanaz Petigara, Julie M. Skinner
Assignee:	Merck Sharp and Dohme LLC
Application Number:	US16/717,509
Patent Claims:	see list of patent claims

Details for Patent 11,642,406

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Wyeth Pharmaceuticals Llc	PREVNAR 13	pneumococcal 13-valent conjugate vaccine (diphtheria crm197 protein)	Injection	125324	February 24, 2010	⤷ Start Trial	2039-12-17
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 11,642,406

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Country	Patent Number	Estimated Expiration
South Africa	202104162	⤷ Start Trial
World Intellectual Property Organization (WIPO)	2020131763	⤷ Start Trial
United States of America	2024382576	⤷ Start Trial
United States of America	2023338498	⤷ Start Trial
United States of America	2023277644	⤷ Start Trial
United States of America	2022296695	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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