Last Updated: October 2, 2026

Patent: 11,046,750

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Summary for Patent: 11,046,750

Title:	Factor VIII proteins having ancestral sequences, expression vectors, and uses related thereto
Abstract:	This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.
Inventor(s):	H. Trent Spencer, Christopher B. Doering, Philip M. Zakas, Eric Gaucher
Assignee:	Emory University , Georgia Tech Research Corp
Application Number:	US16/874,121
Patent Claims:	see list of patent claims

Details for Patent 11,046,750

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Valeant Pharmaceuticals Luxembourg S.à.r.l.	SILIQ	brodalumab	Injection	761032	February 15, 2017	⤷ Start Trial	2040-05-14
Bausch Health Ireland, Limited	SILIQ	brodalumab	Injection	761032	15-Feb-17	⤷ Start Trial	2040-05-14
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 11,046,750

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2016123200	⤷ Start Trial
United States of America	2021388055	⤷ Start Trial
United States of America	2020277356	⤷ Start Trial
United States of America	2018009873	⤷ Start Trial
United States of America	11897938	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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