Last Updated: November 4, 2026

Patent: 10,874,625

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Summary for Patent: 10,874,625

Title:	Methods for the biosynthesis of taurine or hypotaurine in cells
Abstract:	The present invention describes an approach to increase taurine or hypotaurine production in prokaryotes. More particularly, the invention relates to genetic transformation of organisms with genes that encode proteins that catalyze the conversion of cysteine to taurine, methionine to taurine, cysteamine to taurine, or alanine to taurine. The invention describes methods for the use of polynucleotides that encode cysteine dioxygenase (CDO) and sulfinoalanine decarboxylase (SAD) polypeptides in prokaryotes to increase taurine, hypotaurine or taurine precursor production. The preferred embodiment of the invention is in plants but other organisms may be used. Increased taurine production in prokaryotes could be used as nutraceutical, pharmaceutical, or therapeutic compounds or as a supplement in animal feed.
Inventor(s):	Frank J. Turano, Kathleen A. Turano, Peter S. Carlson, Alan M. Kinnersley
Assignee:	Plant Sensory Systems LLC
Application Number:	US16/154,204
Patent Claims:	see list of patent claims

Details for Patent 10,874,625

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Mannkind Corporation	AFREZZA	insulin human	Powder	022472	June 27, 2014	10,874,625	2038-10-08
Mannkind Corporation	AFREZZA	insulin human	Powder	022472	April 17, 2015	10,874,625	2038-10-08
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,874,625

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Country	Patent Number	Estimated Expiration
Brazil	112012010394	⤷ Start Trial
United States of America	10092527	⤷ Start Trial
United States of America	2012222148	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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