Patent: 10,821,160
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Summary for Patent: 10,821,160
| Title: | L-asparaginase variants and fusion proteins with reduced L-glutaminase activity and enhanced stability |
| Abstract: | Variant L-asparaginases with reduced L-glutaminase activity and enhanced in vivo circulation are described as are fusion proteins containing an L-asparaginase and three tandem soluble domains of TRAIL for use in the treatment of cancers such as acute lymphoblastic leukemia and acute myeloid leukemia. |
| Inventor(s): | Lavie Arnon, Nguyen Hien-Anh |
| Assignee: | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS |
| Application Number: | US16080435 |
| Patent Claims: | see list of patent claims |
Details for Patent 10,821,160
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Recordati Rare Diseases, Inc. | ELSPAR | asparaginase | For Injection | 101063 | January 10, 1978 | 10,821,160 | 2037-03-01 |
| Jazz Pharmaceuticals, Inc. | ERWINAZE | asparaginase erwinia chrysanthemi | For Injection | 125359 | November 18, 2011 | 10,821,160 | 2037-03-01 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
