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Last Updated: December 16, 2025

Claims for Patent: 10,821,160

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Summary for Patent: 10,821,160

Title:	L-asparaginase variants and fusion proteins with reduced L-glutaminase activity and enhanced stability
Abstract:	Variant L-asparaginases with reduced L-glutaminase activity and enhanced in vivo circulation are described as are fusion proteins containing an L-asparaginase and three tandem soluble domains of TRAIL for use in the treatment of cancers such as acute lymphoblastic leukemia and acute myeloid leukemia.
Inventor(s):	Lavie Arnon, Nguyen Hien-Anh
Assignee:	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Application Number:	US16080435
Patent Claims:

Details for Patent 10,821,160

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	January 10, 1978	⤷ Get Started Free	2037-03-01
Jazz Pharmaceuticals, Inc.	ERWINAZE	asparaginase erwinia chrysanthemi	For Injection	125359	November 18, 2011	⤷ Get Started Free	2037-03-01
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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