Last Updated: September 24, 2026

Patent: 10,626,431

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Summary for Patent: 10,626,431

Title:	Method for improved isolation of recombinantly produced proteins
Abstract:	The present invention provides a method for increasing the yield of a protein produced by cultivating eukaryotic cells and adding an ionic substance to the culture medium prior to harvest of the protein. Suitable ionic substances are the salts of the Hofmeister series, amino acids and peptone.
Inventor(s):	Stefan Winge
Assignee:	Octapharma AG
Application Number:	US15/199,585
Patent Claims:	see list of patent claims

Details for Patent 10,626,431

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Octapharma Pharmazeutika Produktionsges.m.b.h.	NUWIQ	antihemophilic factor (recombinant)	For Injection	125555	4-Sep-15	10,626,431	2036-06-30
Octapharma Pharmazeutika Produktionsges.m.b.h.	NUWIQ	antihemophilic factor (recombinant)	For Injection	125555	7-Jul-17	10,626,431	2036-06-30
Octapharma Pharmazeutika Produktionsges.m.b.h.	NUWIQ	antihemophilic factor (recombinant)	For Injection	125555	7-Dec-21	10,626,431	2036-06-30
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,626,431

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Country	Patent Number	Estimated Expiration
Austria	E490336	⤷ Start Trial
Germany	602006018587	⤷ Start Trial
Denmark	1863920	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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