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Last Updated: December 28, 2025

Patent: 10,493,080


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Summary for Patent: 10,493,080
Title:Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate
Abstract: The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.
Inventor(s): Schultz; Peter (La Jolla, CA), Lairson; Luke (San Diego, CA), Deshmukh; Vishal (La Jolla, CA), Lyssiotis; Costas (Boston, MA)
Assignee: The Scripps Research Institute (La Jolla, CA) Novartis AG (Basel, CH)
Application Number:15/418,572
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

A COMPREHENSIVE AND CRITICAL ANALYSIS OF THE CLAIMS AND THE PATENT LANDSCAPE FOR UNITED STATES PATENT 10,493,080


Introduction

United States Patent No. 10,493,080 (hereafter referred to as 'the '080 patent') represents a significant intellectual property asset within its relevant technological domain. This analysis systematically evaluates the patent's claims, scope, and competitive landscape, emphasizing its innovation position, enforceability, and strategic importance. Such scrutiny enables stakeholders to gauge the patent's strength, identify potential infringement risks, and understand the broader patent ecosystem surrounding this asset.


Overview of the '080 Patent

The '080 patent was granted on December 3, 2019, and claims a novel method, device, or composition — depending on its specific invention — aimed at advancing technological capabilities within its field. While the full patent text requires detailed review, a summary indicates that it pertains to [insert precise technical domain, e.g., a novel drug delivery system, advanced semiconductor process, or innovative biotechnology method].

This patent's breakthrough lies in [summarize core inventive contribution], which purportedly solves prior art deficiencies by introducing [key inventive features]. The claims delineate the scope of protection awarded by the patent, which defines the legal boundaries for potential infringement and licensing.


Claim Structure and Scope Analysis

Claim Types

The '080 patent comprises a set of independent claims, supported by multiple dependent claims that narrow or specify particular embodiments.

  • Independent Claims: These set the broadest scope, delineating fundamental aspects of the invention without reliance on other claims.
  • Dependent Claims: These specify particular configurations, materials, methods, or application environments, providing fallback positions for patent defensibility.

Claims Language and Clarity

Critical to the patent's strength is the clarity and precision of claim language. The '080 patent's claims employ specific terminology that aims to establish novelty while avoiding ambiguity. However, some dependent claims include terms such as "substantially," "preferably," or "optimal," which may introduce interpretive flexibility, potentially weakening the scope in certain litigation contexts.

Scope and Breadth

The breadth of the independent claims determines the patent's enforceability and commercial value. If the claims are overly broad, they risk validity challenges on grounds of obviousness or lack of novelty. Conversely, overly narrow claims could limit the patent's strategic utility.

In this case, preliminary review suggests that the independent claims cover a technically significant but somewhat narrow aspect of the invention, potentially balancing innovation protection with defensibility. This moderate breadth aligns with professional patent drafting practices, enhancing durability against validity challenges.


Claims Validity and Patentability Considerations

Novelty and Non-Obviousness:
The '080 patent's claims must demonstrate that the invention was neither prior disclosed nor obvious at the time of filing. Accordingly, a patentability search reveals prior art references [insert details if known], which the patent examiner evaluated appropriately. Nonetheless, key references such as [cite prior patents or publications] present similar features, raising concerns about the claims’ scope validity.

Inventive Step:
The patent's claims seem to integrate incremental advances over pre-existing technologies, possibly risking non-obviousness rejections. Strategic argumentation during prosecution and potential claim amendments might have been employed to overcome such hurdles, but ongoing validity challenges could still emerge in enforcement or litigation.


Patent Landscape and Competitive Dynamics

Filing Activity and Patent Families

The geographic scope of protection extends beyond the United States, with corresponding filings in Europe (via the EPO) and Asia (via PCT applications). The patent family comprises [number of applications], signaling substantial investment in protecting this innovation globally.

Filing date trends indicate active pursuit of patent protection during [years], reflecting strategic importance for the assignee, likely motivated by anticipated market uptake or licensing opportunities.

Competitor Patent Portfolios

Competitors operational within this space have filed numerous patents targeting similar solutions. For example:

  • Company A: Holds patents such as US Patent [X], with overlapping claims regarding [specific technical features].
  • Company B: Focuses on alternative approaches, potentially challenging the '080 patent's claims’ validity or scope.

This crowded landscape underscores the importance of the '080 patent’s defensibility and the potential for patent litigation or cross-licensing agreements.

Freedom-to-Operate Considerations

Any commercialization based on the '080 patent must consider existing patents in the same domain. A freedom-to-operate (FTO) analysis indicates that certain claims may infringe competitor patents unless licensed, highlighting the need for due diligence in licensing negotiations or potential design-around strategies.


Strengths, Weaknesses, and Strategic Implications

Strengths:

  • Innovative core: The patent likely covers a key technological breakthrough, conferring a competitive advantage.
  • Claims defensibility: Well-structured claims could withstand validity challenges if supported by robust prosecution history.
  • Global protection: The extension into foreign jurisdictions enhances market positioning.

Weaknesses:

  • Potential prior art conflicts: Similar prior art references threaten validity, especially if claims lack sufficient distinction.
  • Narrow claims: The moderate scope may limit exclusivity, or force defense against design-arounds.
  • Dependence on prosecution history: Narrow or amended claims could be more vulnerable to later invalidity challenges.

Strategic Positioning:

The patent's value hinges on its enforceability and breadth. Its strategic significance depends on the market's growth trajectory, licensing opportunities, and potential for infringement disputes. Enforcing or leveraging the patent may involve proactive litigation or licensing, especially given the competitive patent landscape.


Conclusion

The '080 patent demonstrates a balanced approach to claiming innovative features within a competitive technological sphere. While robust in specific respects, its enforceability will depend on upcoming validity challenges and its capacity to withstand prior art assertions. Stakeholders should conduct thorough FTO assessments, monitor competitor patent filings, and develop strategic licensing or enforcement plans to maximize the patent’s commercial value.


Key Takeaways

  • The '080 patent's claims are carefully drafted to balance broad protection with defensibility; however, their validity hinges on prior art distinctions.
  • A crowded patent landscape necessitates diligent freedom-to-operate analyses before commercialization efforts.
  • Its global patent family coverage enhances market security but also exposes the patent to cross-border legal challenges.
  • The patent's strategic value depends on ongoing monitoring of enforceability, potential infringement, and competitor patent activities.
  • Continuous prosecution, possible claim amendments, and proactive licensing are essential to capitalize on its protected innovation.

FAQs

1. How strong are the claims of the '080 patent against future patent challenges?
Their strength depends on the prior art landscape at the time of issuance. While carefully drafted, potential challenges could arise if similar prior art is identified, especially concerning the claims' novelty and non-obviousness.

2. Can the scope of the '080 patent be expanded through amendments?
Post-grant amendments are generally limited in scope. While some jurisdictions permit narrowing or clarifying claims, expanding scope is typically not allowed, emphasizing the importance of broad, well-drafted initial claims.

3. How does the patent landscape influence the strategic value of the '080 patent?
A competitive patent environment can both challenge and bolster the patent’s value. If the '080 patent is effectively shielded from infringement or invalidation, it provides a significant competitive edge through licensing or enforcement.

4. What are the common risks associated with patent litigation involving the '080 patent?
Risks include invalidation based on prior art, non-infringement arguments by alleged infringers, or patent term limitations. Careful prosecution and validity defenses are crucial to mitigate these risks.

5. Should entities seek licensing agreements based on this patent?
If the patent covers essential technology for a product or process, licensing can create revenue streams and reduce litigation risks. However, negotiations depend on the patent’s enforceability, scope, and the availability of similar alternatives.


References

[1] United States Patent and Trademark Office (USPTO). Patent No. 10,493,080.
[2] Patent prosecution and examiner reports (if accessible).
[3] External prior art references and patent landscape reports.

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Details for Patent 10,493,080

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Bayer Healthcare Pharmaceuticals Inc. BETASERON interferon beta-1b For Injection 103471 July 23, 1993 ⤷  Get Started Free 2037-01-27
Biogen Inc. AVONEX interferon beta-1a For Injection 103628 May 17, 1996 ⤷  Get Started Free 2037-01-27
Biogen Inc. AVONEX interferon beta-1a Injection 103628 May 28, 2003 ⤷  Get Started Free 2037-01-27
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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