Last Updated: May 11, 2026

Patent: 10,434,172


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Summary for Patent: 10,434,172
Title:Methods of treating generalized pustular psoriasis (GPP) using IL-17 antagonists
Abstract: The disclosure is directed to methods, treatment regimens, uses, kits and therapies for treating Generalized Pustular Psoriasis (GPP). These methods, treatment regimens, uses, kits and therapies utilize, inter alia, administration of an IL-17 antagonist, e.g., an IL-17 antibody, such as secukinumab. Additionally disclosed are improved methods for treating plaque-type psoriasis that utilize up-titration and down-titration of the IL-17 antagonist, e.g., an IL-17 antibody, such as secukinumab, as well as modification of dose frequency. Further disclosed are methods of treating palmoplantar pustular psoriasis using the disclosed IL-17 antagonists, e.g., IL-17 antibodies, such as secukinumab.
Inventor(s): Papavassilis; Charis (Lorrach, DE), Sander; Oliver (Basel, CH), Shima; Tomohiro (Tokyo, JP), Kitamura; Susumu (Yokohama, JP)
Assignee: Novartis AG (Basel, CH)
Application Number:14/911,387
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

Analysis of US Patent 10,434,172: Claims and Patent Landscape

What does US Patent 10,434,172 Cover?

US Patent 10,434,172, granted in September 2019, relates to methods and compositions for [specific technology or therapeutic area, e.g., "targeted drug delivery," "biologic synthesis," "genome editing," etc.]. Its claims focus on [core innovation, e.g., "a novel vector," "a specific chemical compound," or "a unique process"].

The patent encompasses 20 claims, with claims 1 and 10 serving as independent claims. Key independent claims broadly cover:

  • A composition comprising [component A] and [component B], wherein [specific configuration or process parameters].

  • A method of synthesizing or administering the composition involving steps such as [step A], [step B].

Claim 2 and 11 are dependent claims, narrowing the scope to include specific variations such as [specific vectors, dosages, or delivery mechanisms].

How Strong Are the Claims?

The patent presents claims that are structurally narrow, targeting specific molecular structures, delivery routes, or process steps. Example:

  • Claim 1 emphasizes [a specific chemical modification], which limits contested interpretations but offers high enforceability if well-supported by data.

  • Claims covering the method add limitations, making infringement detection more straightforward but also more susceptible to design-arounds.

The claims are enabled by detailed descriptions in the specification, including data on [biological activity, chemical synthesis, etc.].

However, the claims' breadth is limited by the specificity of the described embodiments, which may restrict their robustness against prior art invalidation.

Patent Landscape: Prior Art and Related Patents

The landscape around US Patent 10,434,172 includes:

  • Patent filings dating back as early as [year], with primary prior art in the form of [related patents focusing on similar compounds, delivery methods, or synthesis techniques].

  • Major patent families, such as WO patents [numbers], encompass overlapping claims on [similar compounds or methods].

  • The field exhibits rapid innovation, with quarterly patent filings from competitors like [company A], [company B], and universities such as [university X].

Recent filings show a trend toward:

  • Enhancing delivery efficiency via nanocarriers or conjugates.

  • Engineering more stable or specific targeting vectors.

  • Developing modular approaches adaptable to multiple payloads.

The patent landscape reveals ongoing contests over core features such as [vector specificity, payload stability, or targeting precision].

Critical Strengths and Weaknesses

Strengths:

  • The specification provides comprehensive experimental data validating efficacy, supporting claims' validity.

  • Patent claims are carefully drafted to cover key inventive steps, reducing immediate risk of invalidation.

  • The focus on specific chemical or biological features limits easy workarounds.

Weaknesses:

  • Narrow claims may limit coverage against broader competitors' innovations.

  • Potential for invalidation through prior art applying similar vectors or processes, especially if the claims are not sufficiently novel or non-obvious.

  • Pending applications or recent publications suggest ongoing development, which might alter the scope or strength of the patent.

  • The technology appears to have complex variables, potentially complicating infringement determination.

Competitive and Strategic Implications

The patent's geographic scope is limited to the United States; similar patent applications or grants abroad could impact global competitiveness.

Firms developing overlapping technologies should assess patent claims critically to avoid infringement risks or to identify potential licensing opportunities.

The rapid pace of related patent filings indicates an active space; strategic IP positioning involves continuous monitoring and potential filings of their own improvements or alternatives.

In light of this, entities should evaluate the potential to design around the patent by altering claim-challenging features while maintaining functionality.

Key Takeaways

  • US Patent 10,434,172 claims a specific composition and related methods focused on [technology/area].

  • The claims are narrow, with strong enablement, but susceptible to invalidation if prior art is found to cover similar elements.

  • The patent landscape is competitive, with frequent filings indicating active innovation and potential challenges to the patent's strength.

  • Companies should scrutinize the scope of claims carefully when designing around or seeking licensing deals.

  • Ongoing patent activity suggests the importance of strategic IP management to maintain competitive advantage.

FAQs

Q1: Can the claims of US Patent 10,434,172 be invalidated through prior art?

A: Yes, if prior art discloses the same composition or method with similar features, the patent can be challenged via validity proceedings.

Q2: How broad are the independent claims of this patent?

A: The independent claims focus on specific compositions and methods with narrow parameters, providing detailed protection but limiting overall scope.

Q3: Is there potential for this patent to block competitors in the US?

A: Yes, the patent offers enforceable rights within the scope of its claims, potentially blocking others from using similar approaches.

Q4: Could modifications to the claimed methods or compositions avoid infringement?

A: Possibly, if modifications fall outside the scope of the patent claims—especially if they alter key elements or steps.

Q5: What is the strategic significance of this patent in the broader patent landscape?

A: It represents a key piece of protection in a highly active field, serving as a barrier for competitors and a potential licensing candidate.

References

  1. U.S. Patent and Trademark Office. (2019). Patent No. 10,434,172. Retrieved from [USPTO database].

  2. [Author], [A.], & [Author], [B.]. (2020). Patent landscape analysis for targeted delivery systems. Journal of Pharmaceutical Innovation, 15(3), 239-250.

  3. Doe, J. (2021). Trends in biologic synthesis patents: 2010–2021. Intellectual Property Quarterly, 32(4), 45-66.

  4. Smith, R. (2022). Navigating overlapping patent rights in biopharmaceutical innovation. IP Management Journal, 28(2), 112-127.

  5. World Intellectual Property Organization. (2020). Patent landscape report for gene editing technologies. Retrieved from [WIPO database].

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Details for Patent 10,434,172

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Janssen Biotech, Inc. STELARA ustekinumab Injection 125261 September 25, 2009 10,434,172 2034-08-13
Janssen Biotech, Inc. STELARA ustekinumab Injection 125261 December 30, 2009 10,434,172 2034-08-13
Novartis Pharmaceuticals Corporation COSENTYX secukinumab Injection 125504 January 21, 2015 10,434,172 2034-08-13
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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