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Last Updated: October 1, 2020

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Patent: 10,364,451

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Summary for Patent: 10,364,451
Title:Polymer conjugates having reduced antigenicity and methods of using the same
Abstract: Disclosed herein are compositions and methods for reducing the antigenicity of molecules. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone and a plurality of side chains, each side chain covalently attached to the backbone.
Inventor(s): Chilkoti; Ashutosh (Durham, NC), Qi; Yizhi (Durham, NC), Hershfield; Michael S. (Durham, NC), Ganson; Nancy J. (Durham, NC)
Assignee: Duke University (Durham, NC)
Application Number:15/387,536
Patent Claims:see list of patent claims

Details for Patent 10,364,451

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial Duke University (Durham, NC) 2033-05-30 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial Duke University (Durham, NC) 2033-05-30 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Duke University (Durham, NC) 2033-05-30 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Duke University (Durham, NC) 2033-05-30 RX Orphan search
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Duke University (Durham, NC) 2033-05-30 RX search
Emergent ACCRETROPIN somatropin INJECTABLE;INJECTION 021538 001 2008-01-23   Start Trial Duke University (Durham, NC) 2033-05-30 DISCN search
Sandoz OMNITROPE somatropin INJECTABLE;INJECTION 021426 004 2006-05-30   Start Trial Duke University (Durham, NC) 2033-05-30 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 10,364,451

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