Last Updated: November 10, 2026

Patent: 10,301,390

Summary for Patent: 10,301,390

Title:	Anti-IFNAR1 antibodies with reduced Fc ligand affinity
Abstract:	The invention provides anti-IFNAR1 antibodies with reduced affinity for Fc receptors and/or ligands and methods of making and using such antibodies.
Inventor(s):	Anthony Coyle, Peter Kiener, Herren Wu, Ricardo Cibotti
Assignee:	AstraZeneca AB , MedImmune LLC
Application Number:	US15/971,127
Patent Claims:	see list of patent claims

Details for Patent 10,301,390

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Janssen Biotech, Inc.	TREMFYA	guselkumab	Injection	761061	July 13, 2017	⤷ Start Trial	2038-05-04
Janssen Biotech, Inc.	TREMFYA	guselkumab	Injection	761061	January 28, 2019	⤷ Start Trial	2038-05-04
Janssen Biotech, Inc.	TREMFYA	guselkumab	Injection	761061	September 11, 2024	⤷ Start Trial	2038-05-04
Janssen Biotech, Inc.	TREMFYA	guselkumab	Injection	761061	March 25, 2025	⤷ Start Trial	2038-05-04
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,301,390

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Country	Patent Number	Estimated Expiration
Australia	2009212273	⤷ Start Trial
Brazil	122020023189	⤷ Start Trial
Brazil	PI0907735	⤷ Start Trial
Canada	2713981	⤷ Start Trial
China	101952454	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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