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Last Updated: April 26, 2024

Patent: 10,227,403

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Summary for Patent: 10,227,403

Title:	Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
Abstract:	Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM\'s. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-.alpha.-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.
Inventor(s):	Imran; Mir (Los Altos Hills, CA), Morales; Mercedes (San Jose, CA), Korupolu; Radhika (San Jose, CA), To; Elaine (San Jose, CA), Harris; Joel (Mountain View, CA), Hashim; Mir (Fremont, CA)
Assignee:	InCube Labs, LLC (San Jose, CA)
Application Number:	15/144,733
Patent Claims:	see list of patent claims

Details for Patent 10,227,403

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Janssen Biotech, Inc.	REMICADE	infliximab	For Injection	103772	08/24/1998	⤷ Try a Trial	2032-06-25
Immunex Corporation	ENBREL	etanercept	For Injection	103795	11/02/1998	⤷ Try a Trial	2032-06-25
Immunex Corporation	ENBREL	etanercept	For Injection	103795	05/27/1999	⤷ Try a Trial	2032-06-25
Immunex Corporation	ENBREL	etanercept	Injection	103795	09/27/2004	⤷ Try a Trial	2032-06-25
Immunex Corporation	ENBREL	etanercept	Injection	103795	02/01/2007	⤷ Try a Trial	2032-06-25
Immunex Corporation	ENBREL MINI	etanercept	Injection	103795	09/14/2017	⤷ Try a Trial	2032-06-25
Immunex Corporation	ENBREL	etanercept	Injection	103795		⤷ Try a Trial	2032-06-25
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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