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Last Updated: October 1, 2020

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Patent: 10,227,403

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Summary for Patent: 10,227,403
Title:Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins
Abstract: Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM\'s. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-.alpha.-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.
Inventor(s): Imran; Mir (Los Altos Hills, CA), Morales; Mercedes (San Jose, CA), Korupolu; Radhika (San Jose, CA), To; Elaine (San Jose, CA), Harris; Joel (Mountain View, CA), Hashim; Mir (Fremont, CA)
Assignee: InCube Labs, LLC (San Jose, CA)
Application Number:15/144,733
Patent Claims:see list of patent claims

Details for Patent 10,227,403

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Eli Lilly And Co TALTZ ixekizumab INJECTABLE;INJECTION 125521 001 2016-03-22   Start Trial InCube Labs, LLC (San Jose, CA) 2032-06-25 RX search
Novartis Pharms Corp COSENTYX secukinumab INJECTABLE;INJECTION 125504 001 2016-01-15   Start Trial InCube Labs, LLC (San Jose, CA) 2032-06-25 RX search
Abbvie Inc HUMIRA adalimumab VIAL 125057 002 2002-12-31   Start Trial InCube Labs, LLC (San Jose, CA) 2032-06-25 RX search
Abbvie Inc HUMIRA adalimumab SYRINGE 125057 001 2002-12-31   Start Trial InCube Labs, LLC (San Jose, CA) 2032-06-25 RX search
Immunex ENBREL etanercept SYRINGE 103795 002 1998-11-02   Start Trial InCube Labs, LLC (San Jose, CA) 2032-06-25 RX Orphan search
Immunex ENBREL etanercept VIAL; SUBCUTANEOUS 103795 001 1998-11-02   Start Trial InCube Labs, LLC (San Jose, CA) 2032-06-25 RX Orphan search
Centocor Inc REMICADE infliximab VIAL 103772 001 1998-08-24   Start Trial InCube Labs, LLC (San Jose, CA) 2032-06-25 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 10,227,403

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