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Last Updated: September 29, 2020

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Patent: 10,086,072

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Summary for Patent: 10,086,072
Title:Methods of disease activity profiling for personalized therapy management
Abstract: The present invention provides methods for personalized therapeutic management of a disease in order to optimize therapy and/or monitor therapeutic efficacy. In particular, the present invention comprises measuring an array of one or a plurality of biomarkers at a plurality of time points over the course of therapy with a therapeutic agent to determine a mucosal healing index for selecting therapy, optimizing therapy, reducing toxicity, and/or monitoring the efficacy of therapeutic treatment. In certain instances, the therapeutic agent is a TNF.alpha. inhibitor for the treatment of a TNF.alpha.-mediated disease or disorder.
Inventor(s): Singh; Sharat (Rancho Santa Fe, CA), Hoe; Nicholas (San Diego, CA), Lockton; Steve (San Diego, CA), Hauenstein; Scott (San Diego, CA), Ohrmund; Linda (San Diego, CA)
Assignee: Nestec S.A. (Vevey, CH)
Application Number:14/072,746
Patent Claims:see list of patent claims

Details for Patent 10,086,072

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Centocor Inc REMICADE infliximab VIAL 103772 001 1998-08-24   Start Trial Nestec S.A. (Vevey, CH) 2031-05-10 RX Orphan search
Immunex ENBREL etanercept VIAL; SUBCUTANEOUS 103795 001 1998-11-02   Start Trial Nestec S.A. (Vevey, CH) 2031-05-10 RX Orphan search
Immunex ENBREL etanercept SYRINGE 103795 002 1998-11-02   Start Trial Nestec S.A. (Vevey, CH) 2031-05-10 RX Orphan search
Abbvie Inc HUMIRA adalimumab SYRINGE 125057 001 2002-12-31   Start Trial Nestec S.A. (Vevey, CH) 2031-05-10 RX search
Abbvie Inc HUMIRA adalimumab VIAL 125057 002 2002-12-31   Start Trial Nestec S.A. (Vevey, CH) 2031-05-10 RX search
Ucb Inc CIMZIA certolizumab pegol INJECTABLE; INJECTION 125160 001 2008-04-22   Start Trial Nestec S.A. (Vevey, CH) 2031-05-10 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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