Claims for Patent: 9,981,025
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Summary for Patent: 9,981,025
Title: | Anti-drug vaccines |
Abstract: | The present invention relates to anti-drug vaccines based on conjugates between the drug and a non-immunogenic carrier protein. In preferred embodiments, it provides for anti-cocaine vaccines and their use to diminish the effects and/or use of cocaine in a subject. |
Inventor(s): | Deng; Shi-Xian (White Plains, NY), Landry; Donald W. (New York, NY), Kalantarov; Gavreel (Fort Lee, NJ), Trakht; Ilya (Bronx, NY) |
Assignee: | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (New York, NY) |
Application Number: | 14/827,191 |
Patent Claims: | 1. A cocaine pre-hapten having Formula II: ##STR00004## wherein R.sub.1 and R.sub.2 are the same or different, and R.sub.1 and R.sub.2 are independently: unsubstituted or substituted,
branched or unbranched, alkyl; or unsubstituted or substituted, branched or unbranched, alkoxy.
2. A conjugate formed between a cocaine pre-hapten of claim 1, and a serum protein selected from the group consisting of human serum albumin, human alpha 2 macroglobulin, and human immunoglobulin. 3. The conjugate of claim 2, wherein the serum protein is a human immunoglobulin. 4. A composition comprising the conjugate of claim 2, in a suitable carrier. 5. The cocaine pre-hapten of claim 1, wherein one or both of R.sub.1 and R.sub.2 are: unsubstituted or substituted, branched or unbranched, C.sub.1-C.sub.4 alkyl; or unsubstituted or substituted, branched or unbranched, C.sub.1-C.sub.4 alkoxy. 6. The cocaine pre-hapten of claim 1, wherein one or both of R.sub.1 and R.sub.2 are: unsubstituted or substituted, branched or unbranched, C.sub.1-C.sub.2 alkyl; or unsubstituted or substituted, branched or unbranched, C.sub.1-C.sub.2 alkoxy. 7. The cocaine pre-hapten of claim 1, wherein one or both of R.sub.1 and R.sub.2 comprise one or more substituents selected from a hydroxyl (OH) and a ketone (.dbd.O). |
Details for Patent 9,981,025
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Grifols Therapeutics Llc | ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5 | albumin (human) | For Injection | 101138 | 10/21/1942 | ⤷ Try a Trial | 2029-10-22 |
Baxalta Us Inc. | BUMINATE, FLEXBUMIN | albumin (human) | Injection | 101452 | 03/03/1954 | ⤷ Try a Trial | 2029-10-22 |
Csl Behring Ag | ALBURX | albumin (human) | Injection | 102366 | 07/23/1976 | ⤷ Try a Trial | 2029-10-22 |
Grifols Biologicals Llc | ALBUTEIN | albumin (human) | Injection | 102478 | 08/15/1978 | ⤷ Try a Trial | 2029-10-22 |
Instituto Grifols, S.a. | HUMAN ALBUMIN GRIFOLS | albumin (human) | Injection | 103352 | 02/17/1995 | ⤷ Try a Trial | 2029-10-22 |
Instituto Grifols, S.a. | HUMAN ALBUMIN GRIFOLS | albumin (human) | Injection | 103352 | 06/11/2003 | ⤷ Try a Trial | 2029-10-22 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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