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Last Updated: August 4, 2020

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Claims for Patent: 9,958,442

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Summary for Patent: 9,958,442
Title:Sensors incorporating antibodies and methods of making and using the same
Abstract: A sensor comprising an electronic circuit electrically coupled to a type III-V semiconductor material, for example indium arsenide (InAs) and an antibody contacting the type III-V semiconductor material. The sensor produces measurable N changes in the electrical properties of the semiconductor upon antibody-antigen binding events. Electrical properties measurable by the electronic device may include resistivity, capacitance, impedance, and inductance. A method of detecting an antigen using sensors of the invention. A method of detecting a reaction of an analyte to a stimulus using sensors of the invention. Sensor arrays comprising multiple sensors of the invention.
Inventor(s): Angelo; R. Michael (Berkeley, CA), Brown; April S. (Hillsborough, NC), Wolter; Scott (Hillsborough, NC), Lampert; William V. (Raleigh, NC)
Assignee: Duke University (Durham, NC)
Application Number:13/201,181
Patent Claims:1. A sensor comprising: a type III-V semiconductor material having a first edge and a second edge, an antibody contacting the type III-V semiconductor material, and an electronic circuit electrically coupled to the type III-V semiconductor material, the first edge of the type III-V semiconductor material configured for applying current to said first edge and the second edge configured for measuring voltage at said second edge to determine a first value of an electrical property of the semiconductor material, wherein the electronic circuit measures the electrical properly of the type III-V semiconductor material, such that when an antigen binds to the antibody, the electrical property has a second value different from the first value.

2. The sensor of claim 1, wherein the antibody comprises at least one of an IgG protein, an IgA protein, an IgM protein, an IgD protein, and an IgE protein.

3. The sensor of claim 1, wherein the antibody binds an antigen selected from the group consisting of Tumor Necrosis Factor (TNF), Human Serum Albumin (HSA), Interleukin 1.beta. (IL 1.beta.), Interleukin 6 (IL 6), Follicle Stimulating Hormone (FSH), Interferon .gamma., or Human Chorionic Gonadotropin (HCG), and combinations thereof.

4. The sensor of claim 3, wherein the antibody comprises at least one of an IgG protein, an IgA protein, an IgM protein, an IgD protein, and an IgE protein.

5. The sensor of claim 1, wherein the antigen is selected from a prion, a protein, an amino acid, a nucleic acid, a carbohydrate, a hormone, a chemical compound, a chemical reaction intermediate, or a combination thereof.

6. The sensor of claim 5, wherein the antibody comprises at least one of an IgG protein, an IgA protein, an IgM protein, an IgD protein, and an IgE protein.

7. The sensor of claim 1 having a van der Pauw configuration.

8. The sensor of claim 1, further comprising a reservoir positioned to receive an analyte therein and contact the analyte with the type III-V material.

9. The sensor of claim 1, wherein the electrical property is resistivity.

10. The sensor of claim 9, wherein resistivity is sheet resistivity.

11. The sensor of claim 1, wherein the type III-V semiconductor material comprises at least one of indium arsenide (InAs), gallium arsenide (GaAs), gallium nitride (GaN), indium nitride (InN) and a combination thereof.

12. The sensor of claim 1, further comprising an additional antibody, the antibody binding a first antigen, the additional antibody binding a second antigen.

13. The sensor of claim 1, further comprising a well.

14. A sensor array comprising a plurality of sensors of claim 1.

15. The sensor array of claim 14, comprising greater than ten sensors.

16. The sensor array of claim 14, comprising at least two different antibodies.

Summary for Patent:   Start Trial

PCT Information
PCT FiledFebruary 11, 2010PCT Application Number:PCT/US2010/023917
PCT Publication Date:August 26, 2010PCT Publication Number:WO2010/096331

Details for Patent 9,958,442

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Ferring CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017016 004 1975-06-26   Start Trial Duke University (Durham, NC) 2029-02-11 RX search
Ferring CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017016 006 1975-06-26   Start Trial Duke University (Durham, NC) 2029-02-11 RX search
Ferring CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017016 007 1975-06-26   Start Trial Duke University (Durham, NC) 2029-02-11 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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