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Last Updated: April 25, 2024

Claims for Patent: 9,920,122

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Summary for Patent: 9,920,122

Title:	Compositions and methods to enhance the immune system
Abstract:	The invention relates to the field of molecular medicine. In particular, it relates to compositions and methods to enhance the clearance of aberrant cells, e.g. cancer cells or virus-infected cells, by the host\'s immune system. Provided is a composition comprising (i) a therapeutic compound that can trigger a host\'s immune effector cells against an aberrant cell, such as a therapeutic antibody, and (ii) at least one agent capable of reducing or preventing inhibitory signal transduction initiated via SIRPalpha.
Inventor(s):	van den Berg; Timo Kars (Amsterdam, NL)
Assignee:	Stichting Sanquin Bloedvoorziening (Amsterdam, NL)
Application Number:	15/145,365
Patent Claims:	1. A composition comprising (i) a therapeutic compound that can trigger a host's immune effector cells against a cancer cell, wherein said therapeutic compound is a therapeutic antibody comprising a human or non-human primate IgG Fc portion, wherein the therapeutic antibody induces antibody-dependent cellular cytotoxicity (ADCC), and (ii) at least one agent capable of reducing or preventing inhibitory signal transduction initiated via SIRP.alpha., wherein said agent is an anti-SIRP.alpha. antibody or a Fab fragment, a F(ab')2 fragment or a scFv fragment thereof. 2. The composition according to claim 1, wherein the cancer cell is a non-Hodgkin's lymphoma cell, a breast cancer cell, a chronic lymphocytic leukemia cell or a colorectal cancer cell. 3. The composition according to claim 1, wherein the therapeutic antibody is selected from the group consisting of rituximab, trastuzumab, alemtuzumab, cetuximab, and panitumumab. 4. The composition according to claim 3, wherein the cancer cell is a non-Hodgkin's lymphoma cell, a breast cancer cell, a chronic lymphocytic leukemia cell, or a colorectal cancer cell. 5. The composition according to claim 1, wherein the cancer cell is a non-Hodgkin's lymphoma cell or a chronic lymphocytic leukemia cell. 6. The composition according to claim 1, wherein the cancer cell is a breast cancer cell. 7. The composition according to claim 1, wherein the cancer cell is a colorectal cancer cell. 8. The composition according to claim 1, wherein the therapeutic antibody comprises a human IgG1 Fc portion or a human IgG3 Fc portion. 9. A composition comprising (i) a therapeutic antibody selected from the group consisting of rituximab, trastuzumab, alemtuzumab, bevacizumab, cetuximab, and panitumumab, and (ii) at least one agent capable of reducing or preventing inhibitory signal transduction initiated via SIRP.alpha., wherein said agent is an anti-SIRP.alpha. antibody or a Fab fragment, a F(ab')2 fragment or a scFv fragment thereof. 10. The composition according to claim 9, wherein the therapeutic antibody is rituximab. 11. The composition according to claim 10, wherein the cancer cell is a non-Hodgkin's lymphoma cell or a chronic lymphocytic leukemia cell. 12. The composition according to claim 9, wherein the therapeutic antibody is trastuzumab. 13. The composition according to claim 12, wherein the cancer cell is a breast cancer cell. 14. The composition according to claim 9, wherein the therapeutic antibody is alemtuzumab. 15. The composition according to claim 14, wherein the cancer cell is a chronic lymphocytic leukemia cell. 16. The composition of claim 9, wherein the therapeutic antibody is cetuximab. 17. The composition of claim 16, wherein the cancer cell is a colorectal cancer cell.

Details for Patent 9,920,122

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	RITUXAN	rituximab	Injection	103705	11/26/1997	⤷ Try a Trial	2028-04-23
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	09/25/1998	⤷ Try a Trial	2028-04-23
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	02/10/2017	⤷ Try a Trial	2028-04-23
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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