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Last Updated: May 10, 2024

Claims for Patent: 9,896,678

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Summary for Patent: 9,896,678

Title:	Mutant with enhanced secretion of L-asparaginase and its application
Abstract:	The present invention provides a mutant with enhanced secretion of L-asparaginase and its application, which relates to the field of enzyme engineering. This invention successfully constructed a mutant with enhanced secretion of L-asparaginase through N-terminal deletion on amino acid sequence of L-asparaginase, and then expressed the mutant via a recombinant strain. Compared with the wild L-asparaginase, the secretion ability of L-asparaginase mutant in present invention significantly improves by 3.14 times compared to that of wild type. The recombinant strain that constructed in this prevention has an L-asparaginase yield of 407.6 U/mL and a production efficiency of 9.26 U/(mL/h), which reaches to the highest yield been reported.
Inventor(s):	Liu; Song (Wuxi, CN), Feng; Yue (Wuxi, CN), Chen; Jian (Wuxi, CN), Du; Guocheng (Wuxi, CN), Jiao; Yun (Wuxi, CN), Ruan; Jie (Wuxi, CN), Cheng; Hongye (Wuxi, CN), Gao; Hui (Wuxi, CN)
Assignee:	Jiangnan University (Wuxi, Jiangsu, CN)
Application Number:	15/189,139
Patent Claims:	1. An L-asparaginase mutant comprising the amino acid sequence of SEQ ID NO.1. 2. An application of the L-asparaginase mutant of claim 1 in manufacturing medicine, comprising adding the L-asparaginase mutant into a predetermined formulation.

Details for Patent 9,896,678

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978	⤷ Try a Trial	2035-11-25
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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