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Last Updated: May 10, 2024

Claims for Patent: 9,808,523

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Summary for Patent: 9,808,523

Title:	Methods for treatment of brain injury utilizing biologics
Abstract:	A method of using biologics to treat chronic brain injury or spasticity due to stroke, trauma and other causes. Preferred embodiments include perispinal, parenteral, transepidermal or intranasal use of TNF antagonists. The TNF antagonists include TNF receptor fusion proteins, TNF monoclonal antibodies (mAbs), humanized TNF mAbs, fully human TNF mAbs, chimeric TNF mAbs, domain TNF antibodies, mAB fragments, anti-TNF nanobodies, dominant negative TNF constructs and TNF inhibitory single chain antibody fragments. One of the preferred embodiments of this invention is the perispinal administration of etanercept for treatment of mammals following stroke. The use of Trendelenburg positioning, catheters, pumps, or depot formulations are included.
Inventor(s):	Tobinick; Edward Lewis (Boca Raton, FL)
Assignee:	TACT IP LLC (Boca Raton, FL)
Application Number:	14/536,611
Patent Claims:	1. A method for improving motor function, comprising: administering to a human experiencing persistent motor dysfunction after a stroke or traumatic brain injury suffered at least three months previously, a dose containing a therapeutically effective amount of etanercept for improving motor function, wherein said dose is administered parenterally into a perispinal area of said human. 2. The method of claim 1, wherein said persistent motor dysfunction was experienced after a stroke. 3. The method of claim 2, wherein said motor dysfunction is hemiparesis. 4. The method of claim 1, wherein etanercept is administered external to the ligamentum flavum of said human. 5. The method of claim 1, wherein the etanercept is a dimeric fusion protein consisting of two soluble TNF receptors fused to a Fc portion of an immunoglobulin molecule. 6. The method of claim 1, wherein said brain injury occurred at least 24 months previously. 7. The method of claim 1, wherein said motor dysfunction is hemiparesis. 8. The method of claim 6, wherein the etanercept is a dimeric fusion protein consisting of two soluble TNF receptors fused to a Fc portion of an immunoglobulin molecule.

Details for Patent 9,808,523

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Immunex Corporation	ENBREL	etanercept	For Injection	103795	11/02/1998	⤷ Try a Trial	2030-11-01
Immunex Corporation	ENBREL	etanercept	For Injection	103795	05/27/1999	⤷ Try a Trial	2030-11-01
Immunex Corporation	ENBREL	etanercept	Injection	103795	09/27/2004	⤷ Try a Trial	2030-11-01
Immunex Corporation	ENBREL	etanercept	Injection	103795	02/01/2007	⤷ Try a Trial	2030-11-01
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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