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Last Updated: January 1, 2026

Claims for Patent: 9,737,605


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Summary for Patent: 9,737,605
Title:Injectable controlled release composition comprising high viscosity liquid carrier
Abstract:Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.
Inventor(s):Jeremy C. Wright, Wilma Tamraz, John J. Leonard, John W. Gibson, Keith E. Branham, Stefania Sjobeck, Brooks Boyd, Christopher M. Rubino
Assignee: Durect Corp
Application Number:US14/773,642

Details for Patent 9,737,605

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Emergent Biosolutions Canada Inc. ACCRETROPIN somatropin Injection 021538 January 23, 2008 9,737,605 2034-03-11
Novo Nordisk Inc. TRESIBA insulin degludec Injection 203314 September 25, 2015 9,737,605 2034-03-11
Novo Nordisk Inc. TRESIBA insulin degludec Injection 203314 November 21, 2018 9,737,605 2034-03-11
Sanofi-aventis U.s. Llc ADLYXIN lixisenatide Injection 208471 July 27, 2016 9,737,605 2034-03-11
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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