Claims for Patent: 9,737,605
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Summary for Patent: 9,737,605
| Title: | Injectable controlled release composition comprising high viscosity liquid carrier |
| Abstract: | Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection. |
| Inventor(s): | Jeremy C. Wright, Wilma Tamraz, John J. Leonard, John W. Gibson, Keith E. Branham, Stefania Sjobeck, Brooks Boyd, Christopher M. Rubino |
| Assignee: | Durect Corp |
| Application Number: | US14/773,642 |
Details for Patent 9,737,605
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Emergent Biosolutions Canada Inc. | ACCRETROPIN | somatropin | Injection | 021538 | January 23, 2008 | 9,737,605 | 2034-03-11 |
| Novo Nordisk Inc. | TRESIBA | insulin degludec | Injection | 203314 | September 25, 2015 | 9,737,605 | 2034-03-11 |
| Novo Nordisk Inc. | TRESIBA | insulin degludec | Injection | 203314 | November 21, 2018 | 9,737,605 | 2034-03-11 |
| Sanofi-aventis U.s. Llc | ADLYXIN | lixisenatide | Injection | 208471 | July 27, 2016 | 9,737,605 | 2034-03-11 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
International Patent Family for US Patent 9,737,605
| Country | Patent Number | Estimated Expiration |
|---|---|---|
| World Intellectual Property Organization (WIPO) | 2014164754 | ⤷ Get Started Free |
| United States of America | 9572812 | ⤷ Get Started Free |
| United States of America | 2022280646 | ⤷ Get Started Free |
| United States of America | 2021015924 | ⤷ Get Started Free |
| >Country | >Patent Number | >Estimated Expiration |
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